Response of decorin to different intensity treadmill running

Xu,Shao‑Yong; Liu,Sheng‑Yao; Xu,Lei; Deng,Song‑Yun; He,Yong‑Bin; Li,Shu‑Fen; Ni,Guo‑Xin

doi:10.3892/mmr.2018.8802

Response of decorin to different intensity treadmill running

Authors:
- Shao‑Yong Xu
- Sheng‑Yao Liu
- Lei Xu
- Song‑Yun Deng
- Yong‑Bin He
- Shu‑Fen Li
- Guo‑Xin Ni
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Affiliations: Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: March 28, 2018 https://doi.org/10.3892/mmr.2018.8802
Pages: 7911-7917

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Abstract

Decorin is widely understood to affect collagen fibrillogenesis. However, little is understood about its response to various mechanical loading conditions. In the present study, 36 Wistar rats were randomly divided into control (CON), moderate treadmill running (MTR) and strenuous treadmill running (STR) groups. Animals in the MTR and STR groups were subjected to a 4‑ or 8‑week treadmill running protocol. Subsequently, all Achilles tendons were harvested to perform histological and biochemical analyses. Decorin expression was markedly increased in the MTR group compared with the CON group at 4 and 8 weeks. Conversely, decorin expression was markedly decreased in the STR group compared with the CON and MTR group at 4 and 8 weeks. Furthermore, between the two time points, decorin expression levels were significantly increased in the MTR group, whereas they were markedly decreased in the STR group. These results suggested that MTR exercise may induce increased decorin expression via a balance of MMP‑2 and TIMP‑2, improving tendon structure and function. However, STR exercise may result in degradation of decorin due to an imbalance of MMP‑2 and TIMP‑2, with a bias to MMP‑2, resulting in a predisposition to tendinopathy.

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