Open Access

Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma

  • Authors:
    • Li Yi
    • Luqing Tong
    • Tao Li
    • Long Hai
    • Iruni Roshanie Abeysekera
    • Zhennan Tao
    • Haiwen Ma
    • Peidong Liu
    • Yang Xie
    • Jiabo Li
    • Feng Yuan
    • Shengping Yu
    • Xuejun Yang
  • View Affiliations

  • Published online on: May 11, 2018     https://doi.org/10.3892/mmr.2018.9011
  • Pages: 741-748
  • Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma multiforme (GBM) is one of the most lethal types of tumour, despite severe treatment methods. The Cancer Genome Atlas has categorised GBMs into proneural, neural, classical and mesenchymal subtypes; the mesenchymal subgroup has the worst prognosis. CXCR4 has been reported as selectively overexpressed in the mesenchymal subtype and positively associated with MES markers. However, to the best of our knowledge the underlying mechanisms regarding how CXCR4 may regulate mesenchymal GBM are still unknown. The present study aimed to investigate the critical pathways mediated by CXCR4 in mesenchymal GBM using bioinformatic analyses. The results suggested that CXCR4 is a predictor of poor prognosis and may serve as a biomarker of the mesenchymal subtype in patients with GBM. In addition, CXCR4 mediated the mitogen‑activated protein kinase signaling pathway, which was identified specifically in patients with mesenchymal GBM. CXCR4 associated genes or pathways may be a ‘basket trial’ option for the management of melanoma, prostate cancer and mesenchymal GBM.
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July-2018
Volume 18 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yi L, Tong L, Li T, Hai L, Abeysekera IR, Tao Z, Ma H, Liu P, Xie Y, Li J, Li J, et al: Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma. Mol Med Rep 18: 741-748, 2018
APA
Yi, L., Tong, L., Li, T., Hai, L., Abeysekera, I.R., Tao, Z. ... Yang, X. (2018). Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma. Molecular Medicine Reports, 18, 741-748. https://doi.org/10.3892/mmr.2018.9011
MLA
Yi, L., Tong, L., Li, T., Hai, L., Abeysekera, I. R., Tao, Z., Ma, H., Liu, P., Xie, Y., Li, J., Yuan, F., Yu, S., Yang, X."Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma". Molecular Medicine Reports 18.1 (2018): 741-748.
Chicago
Yi, L., Tong, L., Li, T., Hai, L., Abeysekera, I. R., Tao, Z., Ma, H., Liu, P., Xie, Y., Li, J., Yuan, F., Yu, S., Yang, X."Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma". Molecular Medicine Reports 18, no. 1 (2018): 741-748. https://doi.org/10.3892/mmr.2018.9011