Open Access

Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization

  • Authors:
    • Biao Ma
    • Yang Yang
    • Zhituo Li
    • Dali Zhao
    • Weihui Zhang
    • Yanfeng Jiang
    • Dongbo Xue
  • View Affiliations

  • Published online on: September 14, 2018     https://doi.org/10.3892/mmr.2018.9486
  • Pages: 4313-4320
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In recent years, an increasing number of studies on the roles of macrophages in tumors, immune responses and metabolism have been published, in which macrophage polarization has been an extensively discussed topic. In the present study, differentially expressed genes in various types of macrophages were analyzed using the Gene Expression Omnibus database. Cluster analysis of differentially expressed genes was conducted, and a protein‑protein interaction (PPI) network was constructed. Finally, modular analysis and functional enrichment analysis revealed that a Toll‑like receptor (TLR) signaling pathway is involved in the regulation of macrophage polarization. Furthermore, the high‑degree proteins in the PPI network that are involved in the molecular regulation of macrophage polarization are closely associated with proteins of the TLR signaling pathway. These results suggested that the TLR signaling pathways may be a principal direction of future research on the regulation of macrophage polarization.
View Figures
View References

Related Articles

Journal Cover

November-2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ma B, Yang Y, Li Z, Zhao D, Zhang W, Jiang Y and Xue D: Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization. Mol Med Rep 18: 4313-4320, 2018
APA
Ma, B., Yang, Y., Li, Z., Zhao, D., Zhang, W., Jiang, Y., & Xue, D. (2018). Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization. Molecular Medicine Reports, 18, 4313-4320. https://doi.org/10.3892/mmr.2018.9486
MLA
Ma, B., Yang, Y., Li, Z., Zhao, D., Zhang, W., Jiang, Y., Xue, D."Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization". Molecular Medicine Reports 18.5 (2018): 4313-4320.
Chicago
Ma, B., Yang, Y., Li, Z., Zhao, D., Zhang, W., Jiang, Y., Xue, D."Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization". Molecular Medicine Reports 18, no. 5 (2018): 4313-4320. https://doi.org/10.3892/mmr.2018.9486