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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2018 Volume 18 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells

Zhiming Wu, Huangen Wang, Sunyang Fang, Chaoyang Xu
Pages: 4163-4174
Published online on: 03 September 2018

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Article Open Access

Anti‑breast cancer activity of selected 1,3,5‑triazines via modulation of EGFR‑TK

Weixin Yan, Yiyang Zhao, Jianrong He
Pages: 4175-4184
Published online on: 24 August 2018

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Article Open Access

Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma

Lingqi Zhou, Hai Tang, Fang Wang, Lizhi Chen, Shanshan Ou, Tong Wu, Jie Xu, Kaihua Guo
Pages: 4185-4196
Published online on: 21 August 2018

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Article Open Access

Network analysis of membranous glomerulonephritis based on metabolomics data

Amir Taherkhani, Shiva Kalantari, Afsaneh Arefi Oskouie, Mohsen Nafar, Mohammad Taghizadeh, Koorosh Tabar
Pages: 4197-4212
Published online on: 12 September 2018

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Article Open Access

Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yuan
Pages: 4213-4218
Published online on: 10 September 2018

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Article Open Access

Protective effects of α‑2‑macroglobulin on human bone marrow mesenchymal stem cells in radiation injury

Yang Liu, Wanting Cao, Xiangbo Kong, Jie Li, Xueying Chen, Yaping Ge, Wanzhen Zhong, Silian Fang
Pages: 4219-4228
Published online on: 04 September 2018

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Article Open Access

Comprehensive analysis of multi Ewing sarcoma microarray datasets identifies several prognosis biomarkers

Xuqing Yin, Jiubo Sun, Haiyang Zhang, Shuai Wang
Pages: 4229-4238
Published online on: 03 September 2018

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Article Open Access

Long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 controls glioma cell proliferation and apoptosis via regulation of the microRNA‑224‑5p/tumor protein D52 axis

Yongqiang Zhang, Ying Li, Jing Wang, Ping Lei
Pages: 4239-4246
Published online on: 14 September 2018

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Article Open Access

Distribution and prognostic value of tumor‑infiltrating T cells in breast cancer

Shaoda Meng, Li Li, Meiling Zhou, Wanjie Jiang, Heng Niu, Kunxian Yang
Pages: 4247-4258
Published online on: 05 September 2018

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Article Open Access

BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway

Ying‑Bin Wang, Jian‑Qin Xie, Wei Liu, Rong‑Zhi Zhang, Sheng‑Hui Huang, Yan‑Hong Xing
Pages: 4259-4270
Published online on: 04 September 2018

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Article Open Access

Genetic mutation of familial dilated cardiomyopathy based on next‑generation semiconductor sequencing

Xin‑Fu Lin, Jie‑Wei Luo, Gui Liu, Yao‑Bin Zhu, Zhao Jin, Xing Lin
Pages: 4271-4280
Published online on: 05 September 2018

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Article Open Access

Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation

Younju Lee, Jinuk Na, Myung Sun Lee, Eun Young Cha, Ji Young Sul, Jun Beom Park, Jin Sun Lee
Pages: 4281-4288
Published online on: 14 September 2018

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Article Open Access

Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis

Xinyu Hu, Shanshan Teng, Jiawei He, Xiaoqi Sun, Mingzhao Du, Ling Kou, Xiaofeng Wang
Pages: 4289-4296
Published online on: 13 September 2018

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Article Open Access

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease

Chunshuang Xu, Guili Liu, Huihui Ji, Weihua Chen, Dongjun Dai, Zhongming Chen, Dongsheng Zhou, Lei Xu, Haochang Hu, Wei Cui, Lan Chang, Qin Zha, Liping Li, Shiwei Duan, Qinwen Wang
Pages: 4297-4302
Published online on: 24 August 2018

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Article Open Access

Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis

Huaqin Sun, Zhipeng Ye, Ning Li, Fa Jin, Jiuliang Yan, Keren Wu
Pages: 4303-4312
Published online on: 03 September 2018

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Article Open Access

Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization

Biao Ma, Yang Yang, Zhituo Li, Dali Zhao, Weihui Zhang, Yanfeng Jiang, Dongbo Xue
Pages: 4313-4320
Published online on: 14 September 2018

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Article Open Access

Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide‑exposed cells

Xian Wu, Wei Zhou, Qingshuang Wei, Peng Chen, Yan Li
Pages: 4321-4327
Published online on: 14 September 2018

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Article Open Access

Protein phosphatase 2A regulates the p38 signaling pathway to affect the migration of astrocytes

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Jianhua Zhao, Sibei Ji
Pages: 4328-4334
Published online on: 24 August 2018

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Article Open Access

Deletion of poly(ADP‑ribose) polymerase-1 changes the composition of the microbiome in the gut

András Vida, Gábor Kardos, Tünde Kovács, Balázs L. Bodrogi, Péter Bai
Pages: 4335-4341
Published online on: 10 September 2018

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Article Open Access

Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation

Yuanhan Chen, Xingchen Zhao, Jiaxin Li, Li Zhang, Ruizhao Li, Hong Zhang, Ruyi Liao, Shuangxin Liu, Wei Shi, Xinling Liang
Pages: 4342-4348
Published online on: 03 September 2018

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Article Open Access

Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes

Hangyu Tian, Dan Yu, Yan Hu, Pan Zhang, Yang Yang, Qiang Hu, Ming Li
Pages: 4349-4355
Published online on: 04 September 2018

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Article Open Access

Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer

Xi Liu, Xiaodong Wei, Wei Niu, Dong Wang, Bo Wang, Hao Zhuang
Pages: 4356-4364
Published online on: 07 September 2018

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Article Open Access

Molecular pathogenesis involved in human idiopathic pulmonary fibrosis based on an integrated microRNA‑mRNA interaction network

Lijing Wang, Wei Huang, Lemeng Zhang, Qiong Chen, Hongjun Zhao
Pages: 4365-4373
Published online on: 05 September 2018

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Article Open Access

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

Yongyang Tian, Hong Yin, Xi Deng, Beichuan Tang, Xianjun Ren, Tao Jiang
Pages: 4374-4380
Published online on: 03 September 2018

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Article Open Access

Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells

Xi Wang, Hui Chen, Yiping Wen, Xiaoxin Yang, Qing Han, Ping Jiang, Zaiju Huang, Jing Cai, Zehua Wang
Pages: 4381-4387
Published online on: 04 September 2018

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Article Open Access

Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization

Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu
Pages: 4388-4398
Published online on: 03 September 2018

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Article Open Access

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

Dandan Li, Weiying Ren, Zhilong Jiang, Lei Zhu
Pages: 4399-4409
Published online on: 24 August 2018

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Article Open Access

Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion

Hui‑Li Yang, Kai‑Kai Chang, Jie Mei, Wen‑Jie Zhou, Li‑Bing Liu, Li Yao, Yi Meng, Ming‑Yan Wang, Si‑Yao Ha, Zhen‑Zhen Lai, Jiang‑Feng Ye, Da‑Jin Li, Ming‑Qing Li
Pages: 4410-4416
Published online on: 24 August 2018

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Article Open Access

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Wen‑Bo Yu, Liang Cao, Yan‑Yin Zhao, Wei Xiao, Bao‑Guo Xiao
Pages: 4417-4427
Published online on: 04 September 2018

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Article Open Access

FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease Corrigendum in /10.3892/mmr.2024.13172

Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zhou
Pages: 4428-4438
Published online on: 14 September 2018

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Article Open Access

Two Paired Box 6 mutations identified in Chinese patients with classic congenital aniridia and cataract

Ying Lin, Hongbin Gao, Yi Zhu, Chuan Chen, Tao Li, Bingqian Liu, Cancan Lyu, Ying Huang, Haichun Li, Qingxiu Wu, Chenjin Jin, Xiaoling Liang, Xinhua Huang, Lin Lu
Pages: 4439-4445
Published online on: 10 September 2018

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Article Open Access

Using Illumina Infinium HumanMethylation 450K BeadChip to explore genome‑wide DNA methylation profiles in a human hepatocellular carcinoma cell line

Ning Sun, Jialin Zhang, Chengshuo Zhang, Yue Shi, Bochao Zhao, Ao Jiao, Baomin Chen
Pages: 4446-4456
Published online on: 03 September 2018

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Article Open Access

Adoptive transfer of xenoantigen‑stimulated T cell receptor Vβ‑restricted human regulatory T cells prevents porcine islet xenograft rejection in humanized mice

Xi Jin, Min Hu, Lina Gong, Huifang Li, Yan Wang, Ming Ji, Hong Li
Pages: 4457-4467
Published online on: 10 September 2018

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Article Open Access

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Xueyan Chen, Huicai Guo, Qing Li, Yu Zhang, Huanlong Liu, Xiaofei Zhang, Kerang Xie, Zhongning Zhu, Qingfeng Miao, Suwen Su
Pages: 4468-4476
Published online on: 12 September 2018

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Article Open Access

Platelet‑rich fibrin exudate promotes the proliferation and osteogenic differentiation of human periodontal ligament cells in vitro

Xiaoju Li, Huixiao Yang, Zijiian Zhang, Zhonghai Yan, Huling Lv, Yan Zhang, Bin Wu
Pages: 4477-4485
Published online on: 10 September 2018

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Article Open Access

Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats

Yu Wang, Xiaofeng Wang, Wei Liu, Lichun Zhang
Pages: 4486-4498
Published online on: 03 September 2018

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Article Open Access

Identification of key genes and associated pathways in KIT/PDGFRA wild‑type gastrointestinal stromal tumors through bioinformatics analysis

Wen‑Jie Wang, Hong‑Tao Li, Jian‑Ping Yu, Yu‑Min Li, Xiao‑Peng Han, Peng Chen, Wen‑Wen Yu, Wei‑Kai Chen, Zuo‑Yi Jiao, Hong‑Bin Liu
Pages: 4499-4515
Published online on: 05 September 2018

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Article Open Access

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury

Xiaoli Niu, Simin Zheng, Hongtao Liu, Siyuan Li
Pages: 4516-4522
Published online on: 06 September 2018

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Article Open Access

Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia‑reperfusion

Bing Wang, Hua Xu, Jian Li, Hong‑Mei Gao, Ying‑Hong Xing, Zhu Lin, Hong‑Jie Li, Yong‑Qiang Wang, Shu‑Hua Cao
Pages: 4523-4529
Published online on: 14 September 2018

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Article

Aldehyde dehydrogenase activity in cryopreserved cord blood cells for quality assessment prior to transplantation

Junko Ikemoto, Satoshi Yoshihara, Tamami Kobayashi, Shunro Kai, Yoshihiro Fujimori
Pages: 4530-4534
Published online on: 13 September 2018

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Article

Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway

Yinqiang Xin, Peiling Ben, Qi Wang, Yanyan Zhu, Zhimin Yin, Lan Luo
Pages: 4535-4542
Published online on: 05 September 2018

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Article

Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma

Chunyao Li, Lanshan Huang, Huiping Lu, Wei Wang, Gang Chen, Yongyao Gu, Qianping Zhou, Zhigang Peng, Zhenbo Feng
Pages: 4543-4554
Published online on: 03 September 2018

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Article

Epigallocatechin‑3‑gallate protects against secondary osteoporosis in a mouse model via the Wnt/β‑catenin signaling pathway

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Jinlong Li, Lixin Guo, Haibin Xue, Guangsen Wu
Pages: 4555-4562
Published online on: 03 September 2018

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Article

miRNA‑328 overexpression confers cisplatin resistance in non‑small cell lung cancer via targeting of PTEN

Chunmei Wang, Shijun Wang, Feng'e Ma, Weidan Zhang
Pages: 4563-4570
Published online on: 12 September 2018

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Article

Silencing of perilipin by short hairpin RNA inhibits proliferation and induces apoptosis in liposarcoma cells

Ling‑Xin Meng, Yu‑Xiu Zheng, Mao‑Lei He, Xiao‑Ming Zhou, Shu‑Yan Sun, Zhao‑Jun Ding, Qin Meng, Bing‑Cheng Li, Yan‑Wei Sun
Pages: 4571-4576
Published online on: 05 September 2018

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Article

Protection of insulin‑like growth factor 1 on experimental peripheral neuropathy in diabetic mice

Hua Wang, Hao Zhang, Fuming Cao, Jiaping Lu, Jin Tang, Huizhi Li, Yiyun Zhang, Bo Feng, Zhaosheng Tang
Pages: 4577-4586
Published online on: 03 September 2018

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Article

Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats

Zhijian Wang, Shengbing Liu, Weiwei Pan, Yanjun Guo, Zhongfei Shen
Pages: 4587-4594
Published online on: 03 September 2018

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Article

Huwe1 is a novel mediator of protection of neural progenitor L2.3 cells against oxygen‑glucose deprivation injury

Xiaoqin Jiang, Jiyun Yang, Hedong Li, Yi Qu, Wenming Xu, Haiyan Yu, Yu Tong
Pages: 4595-4602
Published online on: 03 September 2018

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Article

Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway

Zhen Mu, Qing Sun
Pages: 4603-4610
Published online on: 03 September 2018

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Article

Analysis of virulence diversity of 73 Helicobacter pylori strains isolated in Guizhou province, China

Lin Yin, Fang Liu, Changcheng Guo, Qiong Wang, Ke Pan, Liangbi Xu, Yan Xiong, Yingting Chen, Zhenghong Chen
Pages: 4611-4620
Published online on: 05 September 2018

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Article

miR‑3120‑5p acts as a diagnostic biomarker in non‑small cell lung cancer and promotes cancer cell proliferation and invasion by targeting KLF4

Hongwei Xu, Quan Wen
Pages: 4621-4628
Published online on: 04 September 2018

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Article

Association between the methylation of six apoptosis‑associated genes with autism spectrum disorder

Yuanzhi Zhao, Cong Zhou, Hang Yu, Wenwu Zhang, Fang Cheng, Haihang Yu, Dongsheng Zhou, Bin Li, Jing Liu, Jie Dai, Jie Zhong, Min Chen, Tianyi Huang, Ranran Pan, Shiwei Duan, Zhenyu Hu
Pages: 4629-4634
Published online on: 10 September 2018

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Article

Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling

Jiajing Zhao, Yingjue Wang, Xi Wu, Ping Tong, Yaohan Yue, Shurong Gao, Dongping Huang, Jianwei Huang
Pages: 4635-4642
Published online on: 14 September 2018

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Article

Application of medical adhesive inhibits intimal hyperplasia involving the downregulation of ERK1/2 and eNOS levels

Shoudong Chai, Yang Yu, Haiming Li, Mingxin Gao, Bo Li , Chengxiong Gu
Pages: 4643-4649
Published online on: 17 September 2018

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Article

Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012

Joana Marinho‑Dias, João Lobo, Rui Henrique, Inês Baldaque, Carlos Pinho‑Vaz, Luísa Regadas, Rosa Branca, Fernando Campilho, António Campos Jr, Rui Medeiros, Hugo Sousa
Pages: 4650-4656
Published online on: 03 September 2018

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Article

Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e

Leilei Yang, Qian Shen, Yanqiong Xia, Xueheng Lei, Jian Peng
Pages: 4657-4665
Published online on: 03 September 2018

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Article

Attenuated endothelial function is associated with decreased endothelial progenitor cells and nitric oxide in premenopausal diabetic women

Juan Liu, Da‑Jun Hu, Huiyang Yan, Jianbin Liu, Xixong Ai, Zi Ren, Haitao Zeng, Hao He, Zhen Yang
Pages: 4666-4674
Published online on: 04 September 2018

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Article

Ursolic acid alleviates inflammation and against diabetes‑induced nephropathy through TLR4‑mediated inflammatory pathway

Jian Li, Nan Li, Shuangtong Yan, Minyan Liu, Banruo Sun, Yanhui Lu, Yinghong Shao
Pages: 4675-4681
Published online on: 03 September 2018

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Article

SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells

Jiadela Teliewubai, Hongwei Ji, Yuyan Lu, Bin Bai, Shikai Yu, Chen Chi, Yawei Xu, Yi Zhang
Pages: 4682-4690
Published online on: 07 September 2018

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Article

Immunization with lentiviral vector‑modified dendritic cells encoding ubiquitinated hepatitis B core antigen promotes Th1 differentiation and antiviral immunity by enhancing p38 MAPK and JNK activation in HBV transgenic mice

Shenglan Dai, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao Tang
Pages: 4691-4699
Published online on: 14 September 2018

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Article

Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells

Shu‑Chun Kuo, Yingxiao Li, Yung‑Ze Cheng, Wei‑Jing Lee, Juei‑Tang Cheng, Kai‑Chun Cheng
Pages: 4700-4708
Published online on: 10 September 2018

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Structure‑activity associations in novel farrerol derivatives with vasorelaxant properties

Xiaomin Hou, Xiaojiang Qin, Qingshan Li
Pages: 4709-4715
Published online on: 03 September 2018

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Case Report

Sarcomatoid carcinoma of the pancreas: A case report and review of the literature

Yingjun Xie, Yien Xiang, Dan Zhang, Xiaoxiao Yao, Jiyao Sheng, Yongsheng Yang, Xuewen Zhang
Pages: 4716-4724
Published online on: 14 September 2018

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Article

Long noncoding RNA LINC00978 promotes cell proliferation and invasion in non‑small cell lung cancer by inhibiting miR‑6754‑5p

Xinlei Li, Yang Ren, Tie Zuo
Pages: 4725-4732
Published online on: 06 September 2018

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Article

Acute stimulatory effect of tumor necrosis factor on the basolateral 50 pS K channels in the thick ascending limb of the rat kidney

Guoyan Zhang, Shiliang Gui, Weiqun Wang, Dexin Meng, Qingmin Meng, Haiyan Luan, Rixin Zhao, Jiatian Zhang, Hongyu Sui
Pages: 4733-4738
Published online on: 10 September 2018

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Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis

Francesca Pagani, Akansha Trivedi, Deepak Khatri, Daniela Zizioli, Emirena Garrafa, Stefania Mitola, Dario Finazzi
Pages: 4739-4746
Published online on: 13 September 2018

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Article

miR‑501‑3p sensitizes glioma cells to cisplatin by targeting MYCN

Chuan‑Gang Zhang, Fan Yang, Yan‑Hua Li, Yan Sun, Xue‑Jian Liu, Xia Wu
Pages: 4747-4752
Published online on: 05 September 2018

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Article

Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Yipeng Wang, Jinlong Li, Lixin Guo, Guangsen Wu
Pages: 4753-4759
Published online on: 03 September 2018

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LIMD2 targeted by miR‑34a promotes the proliferation and invasion of non‑small cell lung cancer cells

Fei Wang, Zhaoguo Li, Lei Xu, Yongchao Li, Yi Li, Xingbo Zhang, Yue Wang, Dazhong Liu
Pages: 4760-4766
Published online on: 06 September 2018

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Retraction Open Access

[Retracted] BIRC5 is a novel target of peroxisome proliferator‑activated receptor γ in brain microvascular endothelium cells during cerebral ischemia

Mingjing Xu, Xianli Yang, Qing Zeng, He He, Pengcheng Lu, Guozhi Huang
Pages: 4767-4767
Published online on: 22 August 2018

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Correction Open Access

[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

Haiying Shen, Kiyoon Kim, Yoojung Oh, Kyung Sik Yoon, Hyung Hwan Baik, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Choe
Pages: 4768-4768
Published online on: 12 September 2018

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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Correction Open Access

[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Article Open Access

Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Article Open Access

Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Article Open Access

Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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Retraction Open Access

[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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Review Open Access

R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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Article Open Access

PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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Retraction Open Access

[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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