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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2018 Volume 18 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells

Zhiming Wu, Huangen Wang, Sunyang Fang, Chaoyang Xu
Pages: 4163-4174
Published online on: 03 September 2018

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Article Open Access

Anti‑breast cancer activity of selected 1,3,5‑triazines via modulation of EGFR‑TK

Weixin Yan, Yiyang Zhao, Jianrong He
Pages: 4175-4184
Published online on: 24 August 2018

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Article Open Access

Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma

Lingqi Zhou, Hai Tang, Fang Wang, Lizhi Chen, Shanshan Ou, Tong Wu, Jie Xu, Kaihua Guo
Pages: 4185-4196
Published online on: 21 August 2018

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Article Open Access

Network analysis of membranous glomerulonephritis based on metabolomics data

Amir Taherkhani, Shiva Kalantari, Afsaneh Arefi Oskouie, Mohsen Nafar, Mohammad Taghizadeh, Koorosh Tabar
Pages: 4197-4212
Published online on: 12 September 2018

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Article Open Access

Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yuan
Pages: 4213-4218
Published online on: 10 September 2018

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Article Open Access

Protective effects of α‑2‑macroglobulin on human bone marrow mesenchymal stem cells in radiation injury

Yang Liu, Wanting Cao, Xiangbo Kong, Jie Li, Xueying Chen, Yaping Ge, Wanzhen Zhong, Silian Fang
Pages: 4219-4228
Published online on: 04 September 2018

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Article Open Access

Comprehensive analysis of multi Ewing sarcoma microarray datasets identifies several prognosis biomarkers

Xuqing Yin, Jiubo Sun, Haiyang Zhang, Shuai Wang
Pages: 4229-4238
Published online on: 03 September 2018

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Article Open Access

Long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 controls glioma cell proliferation and apoptosis via regulation of the microRNA‑224‑5p/tumor protein D52 axis

Yongqiang Zhang, Ying Li, Jing Wang, Ping Lei
Pages: 4239-4246
Published online on: 14 September 2018

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Article Open Access

Distribution and prognostic value of tumor‑infiltrating T cells in breast cancer

Shaoda Meng, Li Li, Meiling Zhou, Wanjie Jiang, Heng Niu, Kunxian Yang
Pages: 4247-4258
Published online on: 05 September 2018

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Article Open Access

BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway

Ying‑Bin Wang, Jian‑Qin Xie, Wei Liu, Rong‑Zhi Zhang, Sheng‑Hui Huang, Yan‑Hong Xing
Pages: 4259-4270
Published online on: 04 September 2018

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Article Open Access

Genetic mutation of familial dilated cardiomyopathy based on next‑generation semiconductor sequencing

Xin‑Fu Lin, Jie‑Wei Luo, Gui Liu, Yao‑Bin Zhu, Zhao Jin, Xing Lin
Pages: 4271-4280
Published online on: 05 September 2018

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Article Open Access

Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation

Younju Lee, Jinuk Na, Myung Sun Lee, Eun Young Cha, Ji Young Sul, Jun Beom Park, Jin Sun Lee
Pages: 4281-4288
Published online on: 14 September 2018

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Article Open Access

Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis

Xinyu Hu, Shanshan Teng, Jiawei He, Xiaoqi Sun, Mingzhao Du, Ling Kou, Xiaofeng Wang
Pages: 4289-4296
Published online on: 13 September 2018

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Article Open Access

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease

Chunshuang Xu, Guili Liu, Huihui Ji, Weihua Chen, Dongjun Dai, Zhongming Chen, Dongsheng Zhou, Lei Xu, Haochang Hu, Wei Cui, Lan Chang, Qin Zha, Liping Li, Shiwei Duan, Qinwen Wang
Pages: 4297-4302
Published online on: 24 August 2018

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Article Open Access

Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis

Huaqin Sun, Zhipeng Ye, Ning Li, Fa Jin, Jiuliang Yan, Keren Wu
Pages: 4303-4312
Published online on: 03 September 2018

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Article Open Access

Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization

Biao Ma, Yang Yang, Zhituo Li, Dali Zhao, Weihui Zhang, Yanfeng Jiang, Dongbo Xue
Pages: 4313-4320
Published online on: 14 September 2018

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Article Open Access

Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide‑exposed cells

Xian Wu, Wei Zhou, Qingshuang Wei, Peng Chen, Yan Li
Pages: 4321-4327
Published online on: 14 September 2018

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Article Open Access

Protein phosphatase 2A regulates the p38 signaling pathway to affect the migration of astrocytes

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Jianhua Zhao, Sibei Ji
Pages: 4328-4334
Published online on: 24 August 2018

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Article Open Access

Deletion of poly(ADP‑ribose) polymerase-1 changes the composition of the microbiome in the gut

András Vida, Gábor Kardos, Tünde Kovács, Balázs L. Bodrogi, Péter Bai
Pages: 4335-4341
Published online on: 10 September 2018

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Article Open Access

Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation

Yuanhan Chen, Xingchen Zhao, Jiaxin Li, Li Zhang, Ruizhao Li, Hong Zhang, Ruyi Liao, Shuangxin Liu, Wei Shi, Xinling Liang
Pages: 4342-4348
Published online on: 03 September 2018

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Article Open Access

Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes

Hangyu Tian, Dan Yu, Yan Hu, Pan Zhang, Yang Yang, Qiang Hu, Ming Li
Pages: 4349-4355
Published online on: 04 September 2018

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Article Open Access

Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer

Xi Liu, Xiaodong Wei, Wei Niu, Dong Wang, Bo Wang, Hao Zhuang
Pages: 4356-4364
Published online on: 07 September 2018

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Article Open Access

Molecular pathogenesis involved in human idiopathic pulmonary fibrosis based on an integrated microRNA‑mRNA interaction network

Lijing Wang, Wei Huang, Lemeng Zhang, Qiong Chen, Hongjun Zhao
Pages: 4365-4373
Published online on: 05 September 2018

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Article Open Access

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

Yongyang Tian, Hong Yin, Xi Deng, Beichuan Tang, Xianjun Ren, Tao Jiang
Pages: 4374-4380
Published online on: 03 September 2018

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Article Open Access

Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells

Xi Wang, Hui Chen, Yiping Wen, Xiaoxin Yang, Qing Han, Ping Jiang, Zaiju Huang, Jing Cai, Zehua Wang
Pages: 4381-4387
Published online on: 04 September 2018

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Article Open Access

Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization

Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu
Pages: 4388-4398
Published online on: 03 September 2018

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Article Open Access

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

Dandan Li, Weiying Ren, Zhilong Jiang, Lei Zhu
Pages: 4399-4409
Published online on: 24 August 2018

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Article Open Access

Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion

Hui‑Li Yang, Kai‑Kai Chang, Jie Mei, Wen‑Jie Zhou, Li‑Bing Liu, Li Yao, Yi Meng, Ming‑Yan Wang, Si‑Yao Ha, Zhen‑Zhen Lai, Jiang‑Feng Ye, Da‑Jin Li, Ming‑Qing Li
Pages: 4410-4416
Published online on: 24 August 2018

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Article Open Access

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Wen‑Bo Yu, Liang Cao, Yan‑Yin Zhao, Wei Xiao, Bao‑Guo Xiao
Pages: 4417-4427
Published online on: 04 September 2018

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Article Open Access

FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease Corrigendum in /10.3892/mmr.2024.13172

Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zhou
Pages: 4428-4438
Published online on: 14 September 2018

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Article Open Access

Two Paired Box 6 mutations identified in Chinese patients with classic congenital aniridia and cataract

Ying Lin, Hongbin Gao, Yi Zhu, Chuan Chen, Tao Li, Bingqian Liu, Cancan Lyu, Ying Huang, Haichun Li, Qingxiu Wu, Chenjin Jin, Xiaoling Liang, Xinhua Huang, Lin Lu
Pages: 4439-4445
Published online on: 10 September 2018

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Article Open Access

Using Illumina Infinium HumanMethylation 450K BeadChip to explore genome‑wide DNA methylation profiles in a human hepatocellular carcinoma cell line

Ning Sun, Jialin Zhang, Chengshuo Zhang, Yue Shi, Bochao Zhao, Ao Jiao, Baomin Chen
Pages: 4446-4456
Published online on: 03 September 2018

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Article Open Access

Adoptive transfer of xenoantigen‑stimulated T cell receptor Vβ‑restricted human regulatory T cells prevents porcine islet xenograft rejection in humanized mice

Xi Jin, Min Hu, Lina Gong, Huifang Li, Yan Wang, Ming Ji, Hong Li
Pages: 4457-4467
Published online on: 10 September 2018

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Article Open Access

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Xueyan Chen, Huicai Guo, Qing Li, Yu Zhang, Huanlong Liu, Xiaofei Zhang, Kerang Xie, Zhongning Zhu, Qingfeng Miao, Suwen Su
Pages: 4468-4476
Published online on: 12 September 2018

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Article Open Access

Platelet‑rich fibrin exudate promotes the proliferation and osteogenic differentiation of human periodontal ligament cells in vitro

Xiaoju Li, Huixiao Yang, Zijiian Zhang, Zhonghai Yan, Huling Lv, Yan Zhang, Bin Wu
Pages: 4477-4485
Published online on: 10 September 2018

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Article Open Access

Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats

Yu Wang, Xiaofeng Wang, Wei Liu, Lichun Zhang
Pages: 4486-4498
Published online on: 03 September 2018

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Article Open Access

Identification of key genes and associated pathways in KIT/PDGFRA wild‑type gastrointestinal stromal tumors through bioinformatics analysis

Wen‑Jie Wang, Hong‑Tao Li, Jian‑Ping Yu, Yu‑Min Li, Xiao‑Peng Han, Peng Chen, Wen‑Wen Yu, Wei‑Kai Chen, Zuo‑Yi Jiao, Hong‑Bin Liu
Pages: 4499-4515
Published online on: 05 September 2018

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Article Open Access

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury

Xiaoli Niu, Simin Zheng, Hongtao Liu, Siyuan Li
Pages: 4516-4522
Published online on: 06 September 2018

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Article Open Access

Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia‑reperfusion

Bing Wang, Hua Xu, Jian Li, Hong‑Mei Gao, Ying‑Hong Xing, Zhu Lin, Hong‑Jie Li, Yong‑Qiang Wang, Shu‑Hua Cao
Pages: 4523-4529
Published online on: 14 September 2018

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Article

Aldehyde dehydrogenase activity in cryopreserved cord blood cells for quality assessment prior to transplantation

Junko Ikemoto, Satoshi Yoshihara, Tamami Kobayashi, Shunro Kai, Yoshihiro Fujimori
Pages: 4530-4534
Published online on: 13 September 2018

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Article

Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway

Yinqiang Xin, Peiling Ben, Qi Wang, Yanyan Zhu, Zhimin Yin, Lan Luo
Pages: 4535-4542
Published online on: 05 September 2018

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Article

Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma

Chunyao Li, Lanshan Huang, Huiping Lu, Wei Wang, Gang Chen, Yongyao Gu, Qianping Zhou, Zhigang Peng, Zhenbo Feng
Pages: 4543-4554
Published online on: 03 September 2018

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Article

Epigallocatechin‑3‑gallate protects against secondary osteoporosis in a mouse model via the Wnt/β‑catenin signaling pathway

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Jinlong Li, Lixin Guo, Haibin Xue, Guangsen Wu
Pages: 4555-4562
Published online on: 03 September 2018

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Article

miRNA‑328 overexpression confers cisplatin resistance in non‑small cell lung cancer via targeting of PTEN

Chunmei Wang, Shijun Wang, Feng'e Ma, Weidan Zhang
Pages: 4563-4570
Published online on: 12 September 2018

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Article

Silencing of perilipin by short hairpin RNA inhibits proliferation and induces apoptosis in liposarcoma cells

Ling‑Xin Meng, Yu‑Xiu Zheng, Mao‑Lei He, Xiao‑Ming Zhou, Shu‑Yan Sun, Zhao‑Jun Ding, Qin Meng, Bing‑Cheng Li, Yan‑Wei Sun
Pages: 4571-4576
Published online on: 05 September 2018

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Article

Protection of insulin‑like growth factor 1 on experimental peripheral neuropathy in diabetic mice

Hua Wang, Hao Zhang, Fuming Cao, Jiaping Lu, Jin Tang, Huizhi Li, Yiyun Zhang, Bo Feng, Zhaosheng Tang
Pages: 4577-4586
Published online on: 03 September 2018

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Article

Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats

Zhijian Wang, Shengbing Liu, Weiwei Pan, Yanjun Guo, Zhongfei Shen
Pages: 4587-4594
Published online on: 03 September 2018

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Article

Huwe1 is a novel mediator of protection of neural progenitor L2.3 cells against oxygen‑glucose deprivation injury

Xiaoqin Jiang, Jiyun Yang, Hedong Li, Yi Qu, Wenming Xu, Haiyan Yu, Yu Tong
Pages: 4595-4602
Published online on: 03 September 2018

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Article

Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway

Zhen Mu, Qing Sun
Pages: 4603-4610
Published online on: 03 September 2018

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Article

Analysis of virulence diversity of 73 Helicobacter pylori strains isolated in Guizhou province, China

Lin Yin, Fang Liu, Changcheng Guo, Qiong Wang, Ke Pan, Liangbi Xu, Yan Xiong, Yingting Chen, Zhenghong Chen
Pages: 4611-4620
Published online on: 05 September 2018

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Article

miR‑3120‑5p acts as a diagnostic biomarker in non‑small cell lung cancer and promotes cancer cell proliferation and invasion by targeting KLF4

Hongwei Xu, Quan Wen
Pages: 4621-4628
Published online on: 04 September 2018

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Article

Association between the methylation of six apoptosis‑associated genes with autism spectrum disorder

Yuanzhi Zhao, Cong Zhou, Hang Yu, Wenwu Zhang, Fang Cheng, Haihang Yu, Dongsheng Zhou, Bin Li, Jing Liu, Jie Dai, Jie Zhong, Min Chen, Tianyi Huang, Ranran Pan, Shiwei Duan, Zhenyu Hu
Pages: 4629-4634
Published online on: 10 September 2018

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Article

Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling

Jiajing Zhao, Yingjue Wang, Xi Wu, Ping Tong, Yaohan Yue, Shurong Gao, Dongping Huang, Jianwei Huang
Pages: 4635-4642
Published online on: 14 September 2018

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Article

Application of medical adhesive inhibits intimal hyperplasia involving the downregulation of ERK1/2 and eNOS levels

Shoudong Chai, Yang Yu, Haiming Li, Mingxin Gao, Bo Li , Chengxiong Gu
Pages: 4643-4649
Published online on: 17 September 2018

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Article

Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012

Joana Marinho‑Dias, João Lobo, Rui Henrique, Inês Baldaque, Carlos Pinho‑Vaz, Luísa Regadas, Rosa Branca, Fernando Campilho, António Campos Jr, Rui Medeiros, Hugo Sousa
Pages: 4650-4656
Published online on: 03 September 2018

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Article

Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e

Leilei Yang, Qian Shen, Yanqiong Xia, Xueheng Lei, Jian Peng
Pages: 4657-4665
Published online on: 03 September 2018

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Article

Attenuated endothelial function is associated with decreased endothelial progenitor cells and nitric oxide in premenopausal diabetic women

Juan Liu, Da‑Jun Hu, Huiyang Yan, Jianbin Liu, Xixong Ai, Zi Ren, Haitao Zeng, Hao He, Zhen Yang
Pages: 4666-4674
Published online on: 04 September 2018

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Article

Ursolic acid alleviates inflammation and against diabetes‑induced nephropathy through TLR4‑mediated inflammatory pathway

Jian Li, Nan Li, Shuangtong Yan, Minyan Liu, Banruo Sun, Yanhui Lu, Yinghong Shao
Pages: 4675-4681
Published online on: 03 September 2018

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Article

SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells

Jiadela Teliewubai, Hongwei Ji, Yuyan Lu, Bin Bai, Shikai Yu, Chen Chi, Yawei Xu, Yi Zhang
Pages: 4682-4690
Published online on: 07 September 2018

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Article

Immunization with lentiviral vector‑modified dendritic cells encoding ubiquitinated hepatitis B core antigen promotes Th1 differentiation and antiviral immunity by enhancing p38 MAPK and JNK activation in HBV transgenic mice

Shenglan Dai, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao Tang
Pages: 4691-4699
Published online on: 14 September 2018

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Article

Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells

Shu‑Chun Kuo, Yingxiao Li, Yung‑Ze Cheng, Wei‑Jing Lee, Juei‑Tang Cheng, Kai‑Chun Cheng
Pages: 4700-4708
Published online on: 10 September 2018

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Structure‑activity associations in novel farrerol derivatives with vasorelaxant properties

Xiaomin Hou, Xiaojiang Qin, Qingshan Li
Pages: 4709-4715
Published online on: 03 September 2018

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Case Report

Sarcomatoid carcinoma of the pancreas: A case report and review of the literature

Yingjun Xie, Yien Xiang, Dan Zhang, Xiaoxiao Yao, Jiyao Sheng, Yongsheng Yang, Xuewen Zhang
Pages: 4716-4724
Published online on: 14 September 2018

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Article

Long noncoding RNA LINC00978 promotes cell proliferation and invasion in non‑small cell lung cancer by inhibiting miR‑6754‑5p

Xinlei Li, Yang Ren, Tie Zuo
Pages: 4725-4732
Published online on: 06 September 2018

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Article

Acute stimulatory effect of tumor necrosis factor on the basolateral 50 pS K channels in the thick ascending limb of the rat kidney

Guoyan Zhang, Shiliang Gui, Weiqun Wang, Dexin Meng, Qingmin Meng, Haiyan Luan, Rixin Zhao, Jiatian Zhang, Hongyu Sui
Pages: 4733-4738
Published online on: 10 September 2018

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Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis

Francesca Pagani, Akansha Trivedi, Deepak Khatri, Daniela Zizioli, Emirena Garrafa, Stefania Mitola, Dario Finazzi
Pages: 4739-4746
Published online on: 13 September 2018

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Article

miR‑501‑3p sensitizes glioma cells to cisplatin by targeting MYCN

Chuan‑Gang Zhang, Fan Yang, Yan‑Hua Li, Yan Sun, Xue‑Jian Liu, Xia Wu
Pages: 4747-4752
Published online on: 05 September 2018

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Article

Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Yipeng Wang, Jinlong Li, Lixin Guo, Guangsen Wu
Pages: 4753-4759
Published online on: 03 September 2018

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Article

LIMD2 targeted by miR‑34a promotes the proliferation and invasion of non‑small cell lung cancer cells

Fei Wang, Zhaoguo Li, Lei Xu, Yongchao Li, Yi Li, Xingbo Zhang, Yue Wang, Dazhong Liu
Pages: 4760-4766
Published online on: 06 September 2018

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Retraction Open Access

[Retracted] BIRC5 is a novel target of peroxisome proliferator‑activated receptor γ in brain microvascular endothelium cells during cerebral ischemia

Mingjing Xu, Xianli Yang, Qing Zeng, He He, Pengcheng Lu, Guozhi Huang
Pages: 4767-4767
Published online on: 22 August 2018

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Correction Open Access

[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

Haiying Shen, Kiyoon Kim, Yoojung Oh, Kyung Sik Yoon, Hyung Hwan Baik, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Choe
Pages: 4768-4768
Published online on: 12 September 2018

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Journal Cover
August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Article Open Access

Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Review Open Access

Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Article Open Access

Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Article Open Access

Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Article Open Access

Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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Retraction Open Access

[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Review Open Access

Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Review Open Access

Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Review Open Access

Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Article Open Access

Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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Review Open Access

SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Review Open Access

Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Chronic kidney disease‑associated encephalopathy: Clinical features, pathomechanisms and emerging therapeutic strategies (Review)

Nanling Zeng, Ling Jiang, Yang Zhang, Jian Liu, Qiong Zhang, Lishang Liao, Qiongdan Hu
Article Number: 259
Published online on: 21 July 2026

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[Retracted] Emodin promotes the arrest of human lymphoma Raji cell proliferation through the UHRF1‑DNMT3A‑∆Np73 pathways

Yun Lin, Weiming Chen, Zhihong Wang, Pengwei Cai
Article Number: 258
Published online on: 20 July 2026

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Article Open Access

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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Expression of Concern Open Access

[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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Article Open Access

PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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Review Open Access

From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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Correction Open Access

[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Review Open Access

Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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Retraction Open Access

[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Article Open Access

Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Article Open Access

Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Article Open Access

Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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