Open Access

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

  • Authors:
    • Wen‑Bo Yu
    • Liang Cao
    • Yan‑Yin Zhao
    • Wei Xiao
    • Bao‑Guo Xiao
  • View Affiliations

  • Published online on: September 4, 2018     https://doi.org/10.3892/mmr.2018.9450
  • Pages: 4417-4427
  • Copyright : © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Ginkgolide B (GB) and ginkgolide K (GK) are two main active monomers of ginkgolides that present a unique group of diterpenes found naturally in the leaves of the Ginkgo biloba tree. Astrocytes are the most abundant cell type within the central nervous system (CNS) and serve essential roles in maintaining healthy brain function. The present study compared the biological effects of GB and GK on astrocytes exposed to oxygen‑glucose deprivation (OGD). The results demonstrated that GB and GK exhibit many different actions. The level of the platelet‑activating factor (PAF) was elevated on astrocytes exposed to OGD, and inhibited by GB and GK treatment. Although GB and GK inhibited the expression of p‑NF‑κB/p65, GK exerted stronger anti‑inflammatory and antioxidant effects on astrocytes exposed to OGD than GB by inhibiting interleukin (IL)‑6 and tumor necrosis factor‑α, and inducing IL‑10 and the nuclear factor‑erythroid 2‑related factor 2/HO‑1 signaling pathway. When compared with GB treatment, GK treatment maintained high levels of phosphoinositide 3‑kinase/phosphorylated‑protein kinase B expression, and induced a marked upregulation of Wnt family member 1 and brain derived neurotrophic factor, indicating that GK, as a natural plant compound, may have more attractive prospects for clinical application in the treatment of neurological disorders than GB.
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November-2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yu WB, Cao L, Zhao YY, Xiao W and Xiao BG: Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation. Mol Med Rep 18: 4417-4427, 2018
APA
Yu, W., Cao, L., Zhao, Y., Xiao, W., & Xiao, B. (2018). Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation. Molecular Medicine Reports, 18, 4417-4427. https://doi.org/10.3892/mmr.2018.9450
MLA
Yu, W., Cao, L., Zhao, Y., Xiao, W., Xiao, B."Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation". Molecular Medicine Reports 18.5 (2018): 4417-4427.
Chicago
Yu, W., Cao, L., Zhao, Y., Xiao, W., Xiao, B."Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation". Molecular Medicine Reports 18, no. 5 (2018): 4417-4427. https://doi.org/10.3892/mmr.2018.9450