Open Access

Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder

  • Authors:
    • Jun Lu
    • Ling‑Feng Zhu
    • Yuan‑Ming Cai
    • Hui‑Yue Dong
    • Ling Zhu
    • Jian‑Ming Tan
  • View Affiliations

  • Published online on: November 12, 2018     https://doi.org/10.3892/mmr.2018.9646
  • Pages: 187-194
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Various types of mesenchymal stromal cells (MSCs) have been used in urological tissue engineering but to date the existence of MSCs has not been reported in the human bladder. The present study provided evidence that a small number of MSC‑like cells exist in the human bladder and designated this class of cells ‘human bladder‑derived MSC‑like cells’ (hBSCs). It was demonstrated that hBSCs can be cultured to yield a large population. These hBSCs expressed the surface markers of MSCs and exhibited the capacity for osteogenic, adipogenic and chondrogenic differentiation. On induction with appropriate media in vitro, hBSCs could differentiate into bladder‑associated cell types, including urothelial, endothelial and smooth muscle cell‑like lineages. In addition, the average telomerase activity of adult hBSCs was higher compared with adult human bone marrow‑derived MSCs, but lower than that of human umbilical cord Wharton's jelly‑derived MSCs. These findings may inspire future studies on the role of hBSCs in urological tissue engineering applications and in other fields.
View Figures
View References

Related Articles

Journal Cover

January-2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Zhu LF, Cai YM, Dong HY, Zhu L and Tan JM: Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder. Mol Med Rep 19: 187-194, 2019.
APA
Lu, J., Zhu, L., Cai, Y., Dong, H., Zhu, L., & Tan, J. (2019). Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder. Molecular Medicine Reports, 19, 187-194. https://doi.org/10.3892/mmr.2018.9646
MLA
Lu, J., Zhu, L., Cai, Y., Dong, H., Zhu, L., Tan, J."Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder". Molecular Medicine Reports 19.1 (2019): 187-194.
Chicago
Lu, J., Zhu, L., Cai, Y., Dong, H., Zhu, L., Tan, J."Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder". Molecular Medicine Reports 19, no. 1 (2019): 187-194. https://doi.org/10.3892/mmr.2018.9646