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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2019 Volume 19 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Roles of the inflammasome in the gut‑liver axis (Review)

Junfeng Wang, Rui Dong, Shan Zheng
Pages: 3-14
Published online on: 20 November 2018

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Review Open Access

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

Martha Cristina Diaz‑Franco, Raul Franco‑Diaz de Leon, Jose Rafael Villafan‑Bernal
Pages: 15-22
Published online on: 05 November 2018

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Review

Molecular targets of curcumin in breast cancer (Review)

Xinqiang Song, Mu Zhang, Erqin Dai, Yuan Luo
Pages: 23-29
Published online on: 19 November 2018

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Article Open Access

Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis

Rongqiang Zhang, Xiaoli Yang, Jing Wang, Lixin Han, Aimin Yang, Jie Zhang, Dandan Zhang, Baorong Li, Zhaofang Li, Yongmin Xiong
Pages: 30-40
Published online on: 20 November 2018

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Article Open Access

Hyperoside decreases the apoptosis and autophagy rates of osteoblast MC3T3‑E1 cells by regulating TNF‑like weak inducer of apoptosis and the p38mitogen activated protein kinase pathway

Qing Zhang, Xiao‑Feng Zhang
Pages: 41-50
Published online on: 02 November 2018

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Article Open Access

Long‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse

Wanming Cui, Haolin Wang, Yu Cheng, Xiaorui Ma, Yu Lei, Xingxing Ruan, Lin Shi, Mei Lv
Pages: 51-58
Published online on: 05 November 2018

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Article Open Access

PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression

Xia Wang, Xu Liu, Yuan Ren, Ying Liu, Shuangyu Han, Jingkang Zhao, Xingchun Gou, Yuan He
Pages: 59-74
Published online on: 12 November 2018

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Article Open Access

PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis

Jie Wu, Sheng Xiao, Miaomiao Yuan, Qianyuan Li, Guangfen Xiao, Wei Wu, Yuexian Ouyang, Lihua Huang, Chenjiao Yao
Pages: 75-84
Published online on: 06 November 2018

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Article Open Access

Downregulation of NLRP2 inhibits HUVEC viability by inhibiting the MAPK signaling pathway

Xiaolu Zhang, Xinlei Lu, Limei Yu, Yufeng Gu, Fuzheng Qu
Pages: 85-92
Published online on: 05 November 2018

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Article Open Access

Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury Corrigendum in /10.3892/mmr.2019.10629

Peiyan Huang, Jun Gu, Junguo Wu, Lei Geng, Yang Hong, Siqun Wang , Minghai Wang
Pages: 93-102
Published online on: 21 November 2018

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Article Open Access

Potential functions of long non‑coding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells

Xiang Sun, Bo Jia, Xiao‑Ling Qiu, Hong‑Xing Chu, Zhao‑Qiang Zhang, Zhi‑Ping Wang, Jian‑Jiang Zhao
Pages: 103-114
Published online on: 20 November 2018

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Article Open Access

Integration of high‑throughput data of microRNA and mRNA expression profiles reveals novel insights into the mechanism of liver fibrosis

Yitong Zhang, Jing Liu, Yanyun Ma, Jingjie Wang, Jie Zhu, Jie Liu, Jun Zhang
Pages: 115-124
Published online on: 09 November 2018

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Article Open Access

Platelet‑derived growth factor D promotes the angiogenic capacity of endothelial progenitor cells

Jianbo Zhang, Haolong Zhang, Yikuan Chen, Jian Fu, Yu Lei, Jianming Sun, Bo Tang
Pages: 125-132
Published online on: 26 November 2018

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Article Open Access

Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo

Guixiang Tian, Xiue Sun, Jingkun Bai, Jinhua Dong, Bo Zhang, Zhiqin Gao, Jingliang Wu
Pages: 133-142
Published online on: 22 November 2018

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Article Open Access

Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis

Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui, Wenxia Meng, Wei Guo, Baoshan Wang
Pages: 143-154
Published online on: 09 November 2018

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Article Open Access

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity

Meiying Feng, Nannan Dang, Yinshan Bai, Hengxi Wei, Li Meng, Kai Wang, Zhihong Zhao, Yun Chen, Fenglei Gao, Zhilin Chen, Li Li, Shouquan Zhang
Pages: 155-164
Published online on: 20 November 2018

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Article Open Access

Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells

Yun‑Qian Guan, Chun‑Song Zhao, Hai‑Qiang Zou, Xiao‑Ming Yan, Lu‑Lu Luo, Jia‑Lin Wu, Xiaobo Li, Yu Alex Zhang
Pages: 165-176
Published online on: 19 November 2018

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Article Open Access

Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways

Simeng Wu, Yajun Wang, Zhe Yuan, Siliang Wang, Hongmei Du, Xue Liu, Qiushi Wang, Xike Zhu
Pages: 177-186
Published online on: 19 November 2018

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Article Open Access

Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder

Jun Lu, Ling‑Feng Zhu, Yuan‑Ming Cai, Hui‑Yue Dong, Ling Zhu, Jian‑Ming Tan
Pages: 187-194
Published online on: 12 November 2018

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Article Open Access

Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone

Lang Gan, Shuguang Pan, Jinchi Cui, Jie Bai, Peng Jiang, Yu He
Pages: 195-204
Published online on: 15 November 2018

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Article Open Access

Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Pages: 205-212
Published online on: 21 November 2018

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Article Open Access

MG132 selectively upregulates MICB through the DNA damage response pathway in A549 cells

Dan Luo, Xi‑Wen Dong, Bing Yan, Mei Liu, Tian‑Hui Xue, Hui Liu, Jun‑Hao You, Fang Li, Zi‑Ling Wang, Zhi‑Nan Chen
Pages: 213-220
Published online on: 20 November 2018

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Article Open Access

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation

Jingxiao Lu, Yang Su, Xianguo Chen, Yuan Chen, Pengcheng Luo, Fangyou Lin, Jie Zhang
Pages: 221-230
Published online on: 21 November 2018

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Article Open Access

P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling

Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xia
Pages: 231-237
Published online on: 15 November 2018

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Article Open Access

Establishment of microRNA, transcript and protein regulatory networks in Alport syndrome induced pluripotent stem cells

Wenbiao Chen, Donge Tang, Yong Dai, Hongyan Diao
Pages: 238-250
Published online on: 20 November 2018

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Article Open Access

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling

Qinchen Cao, Xinxin Wang, Yonggang Shi, Mingzhi Zhang, Jing Yang, Meilian Dong, Yin Mi, Zhigang Zhang, Ke Liu, Li Jiang, Na Wang, Ping Wang
Pages: 251-261
Published online on: 13 November 2018

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Article Open Access

Hepatitis B virus core protein dimer‑dimer interface is critical for viral replication

Chang‑Long Zheng, Yong‑Mei Fu, Zhan‑Xue Xu, Yong Zou, Kai Deng
Pages: 262-270
Published online on: 02 November 2018

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Article Open Access

Hypoxia‑induced miR‑210 contributes to apoptosis of mouse spermatocyte GC‑2 cells by targeting Kruppel‑like factor 7

Jin‑Xing Lv, Jian Zhou, Rui‑Qing Tong, Bin Wang, Xue‑Lei Chen, Yan‑Yan Zhuang, Fei Xia, Xue‑Dong Wei
Pages: 271-279
Published online on: 12 November 2018

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Article Open Access

UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

Xuemei Fan, Jianfa Jiang, Zhiqiang Huang, Jumei Gong, Yiming Wang, Wei Xue, Yan Deng, Yanfang Wang, Tingping Zheng, Aijun Sun, Guoan Luo
Pages: 280-292
Published online on: 12 November 2018

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Article Open Access

The role of E2F8 in the human placenta

Masako Mizuno, Rika Miki, Yoshinori Moriyama, Takafumi Ushida, Kenji Imai, Kaoru Niimi, Tomoko Nakano, Hiroyuki Tsuda, Seiji Sumigama, Eiko Yamamoto, Takeshi Senga, Akira Iwase, Fumitaka Kikkawa, Tomomi Kotani
Pages: 293-301
Published online on: 01 November 2018

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Article Open Access

Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

Hua Li, Zijie Cheng, Yuanyuan Tang, Mengwen Feng, Anwen Yin, Hao Zhang, Jia Xu, Qijun Zhang, Jinsong Zhang, Lingmei Qian
Pages: 302-308
Published online on: 13 November 2018

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Article Open Access

CagA increases DNA methylation and decreases PTEN expression in human gastric cancer

Baogui Zhang, Xiaobei Zhang, Meng Jin, Lei Hu, Mingde Zang, Weilong Qiu, Shouqi Wang, Bingya Liu, Shiqi Liu, Dongli Guo
Pages: 309-319
Published online on: 13 November 2018

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Article Open Access

Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis

Bingqian Wang, Wenna Li, Hezhi Fang, Huaibin Zhou
Pages: 320-326
Published online on: 02 November 2018

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Article Open Access

c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats

Geng‑Qiang Ling, Xian‑Feng Li, Xu‑Hui Lei, Zhen‑Yu Wang, Dong‑Ying Ma, Yue‑Na Wang, Wei Ye
Pages: 327-337
Published online on: 09 November 2018

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Article Open Access

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat Schwann cells in vitro

Qing Li, Yang Jiao, Yang Yu, Guolin Wang, Yonghao Yu
Pages: 338-344
Published online on: 08 November 2018

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Article Open Access

MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines

Nevim Aygun, Oguz Altungoz
Pages: 345-361
Published online on: 22 November 2018

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Article Open Access

Identification of key candidate genes and miRNA‑mRNA target pairs in chronic lymphocytic leukemia by integrated bioinformatics analysis

Chundi Gao, Chao Zhou, Jing Zhuang, Lijuan Liu, Junyu Wei, Cun Liu, Huayao Li, Changgang Sun
Pages: 362-374
Published online on: 09 November 2018

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Article Open Access

Enhanced adhesion and proliferation of bone marrow mesenchymal stem cells on β‑tricalcium phosphate modified by an affinity peptide

Guozong Wang, Zhentao Man, Hua Xin, Yi Li, Changshun Wu, Shui Sun
Pages: 375-381
Published online on: 13 November 2018

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Article Open Access

Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll‑like receptor‑4‑NADPH oxidase 4 signaling pathway

Zhi‑Peng You, Meng‑Jia Yu, Yu‑Lan Zhang, Ke Shi
Pages: 382-390
Published online on: 08 November 2018

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Article Open Access

Genome‑wide DNA methylation analysis of uterosacral ligaments in women with pelvic organ prolapse Corrigendum in /10.3892/mmr.2019.9852

Lifang Zhang, Ping Zheng, Aihong Duan, Yan Hao, Chang Lu, Dan Lu
Pages: 391-399
Published online on: 13 November 2018

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Article Open Access

Visfatin is regulated by interleukin‑6 and affected by the PPAR‑γ pathway in BeWo cells

Yanhong Zhang, Yan Huo, Wenhui He, Suxin Liu, Hongyan Li, Li Li
Pages: 400-406
Published online on: 20 November 2018

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Article Open Access

Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

Guozong Wang, Zhentao Man, Nianping Zhang, Hua Xin, Yi Li, Tiantong Sun, Shui Sun
Pages: 407-413
Published online on: 05 November 2018

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Article Open Access

Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway

Jin Yi, Ruohui Tang, Jing Yang, Yueqi Chen, Jun Fei
Pages: 414-422
Published online on: 15 November 2018

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Article Open Access

Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats

Qiang Jia, Rui Yang, Xiao‑Fen Liu, Shan‑Feng Ma, Lei Wang
Pages: 423-431
Published online on: 09 November 2018

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Article Open Access

Rosuvastatin protects against oxidized low‑density lipoprotein‑induced endothelial cell injury of atherosclerosis in vitro

Jianan Geng, Huali Xu, Xiaofeng Yu, Guoliang Xu, Hongyan Cao, Guangzhu Lin, Dayun Sui
Pages: 432-440
Published online on: 19 November 2018

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Article Open Access

Potential four‑miRNA signature associated with T stage and prognosis of patients with pancreatic ductal adenocarcinoma identified by co‑expression analysis

Lukuan You, Jinliang Wang, Fan Zhang, Jing Zhang, Haitao Tao, Xuan Zheng, Yi Hu
Pages: 441-451
Published online on: 19 November 2018

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Article Open Access

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

Jin Ju Park, Ji Eun Kim, Woo Bin Yun, Mi Rim Lee, Jun Young Choi, Bo Ram Song, Hong Joo Son, Yong Lim, Hyun‑Gu Kang, Beum Soo An, Seung Yun Yang, Sung Baek Seo, Dae Youn Hwang
Pages: 452-460
Published online on: 19 November 2018

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Article Open Access

(R)‑dehydroxyabscisic alcohol β‑D‑apiofuranosyl‑(1ˮ→6ʼ)‑β‑D‑glucopyranoside enhances the osteoblastic differentiation of ST2 cells via the BMP/WNT pathways

Yadong Liu, Tao Yang, Ting Chen, Jun Hao, Yu Gai, Weiguo Zhang
Pages: 461-467
Published online on: 23 November 2018

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Article Open Access

MEK inhibition prevents TGF‑β1‑induced myofibroblast transdifferentiation in human tenon fibroblasts

Jiamin Wen, Xianchai Lin, Wuyou Gao, Bo Qu, Yunlan Ling, Rongjiao Liu, Minbin Yu
Pages: 468-476
Published online on: 20 November 2018

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Article Open Access

Meta‑analysis of current chemotherapy regimens in advanced pancreatic cancer to prolong survival and reduce treatment‑associated toxicities

Jie Chen, Linli Chen, Jianping Yu, Yanmei Xu, Xiaohui Wang, Ziqian Zeng, Ning Liu, Fan Xu, Shu Yang
Pages: 477-489
Published online on: 09 November 2018

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Article Open Access

Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice

Yuzhu Cheng, Zhanlun Ou, Qingguo Li, Juan Yang, Min Hu, Yubin Zhou, Xiaodong Zhuang, Zhenyu Jason Zhang, Shixia Guan
Pages: 490-498
Published online on: 23 November 2018

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Article Open Access

Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy

Qian Wang, Yuxin Sun, Tianshu Li, Lianqin Liu, Yunxia Zhao, Liyuan Li, Ling Zhang, Yan Meng
Pages: 499-507
Published online on: 21 November 2018

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Article Open Access

miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2

Xiaohe Chen, Shouhang Yang, Jue Zeng, Ming Chen
Pages: 508-514
Published online on: 21 November 2018

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Article

SKA2 mediates invasion and metastasis in human breast cancer via EMT

Zhouhui Ren, Tong Yang, Pingping Zhang, Kaitai Liu, Weihong Liu, Ping Wang
Pages: 515-523
Published online on: 02 November 2018

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Article

HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma

Li Dong, Liying Xue, Cuiying Zhang, Hui Li, Zhihui Cai, Ruifang Guo
Pages: 524-532
Published online on: 19 November 2018

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Article

Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5

Yueling Wang, Aijun Jia, Wenjuan Ma
Pages: 533-540
Published online on: 26 November 2018

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Article

Knockdown of P120 catenin aggravates endothelial injury under an impinging flow by inducing breakdown of adherens junctions

Jian‑Lan Zhao, Zhi‑Peng Xiao, Nian‑Zu Yu, Jin‑Wen Jiang, Mei‑Hua Li
Pages: 541-548
Published online on: 13 November 2018

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Article

Dynamic Nestin expression during hair follicle maturation and the normal hair cycle

Ruosi Chen, Yong Miao, Zhiqi Hu
Pages: 549-554
Published online on: 26 November 2018

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Article

Nicotinamide induces liver regeneration and improves liver function by activating SIRT1

Hai‑Feng Wan, Jia‑Xin Li, Hao‑Tian Liao, Ming‑Heng Liao, Lin Luo, Lin Xu, Ke‑Fei Yuan, Yong Zeng
Pages: 555-562
Published online on: 22 November 2018

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Article

(+)‑pinoresinol‑O‑β‑D‑glucopyranoside from Eucommia ulmoides Oliver and its anti‑inflammatory and antiviral effects against influenza A (H1N1) virus infection

Jing Li, Xiaoli Liang, Beixian Zhou, Xiaowei Chen, Peifang Xie, Haiming Jiang, Zhihong Jiang, Zifeng Yang, Xiping Pan
Pages: 563-572
Published online on: 26 November 2018

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Article

Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway

Junyan Wu, Cong Zhang, Chuanjun Liu, Aihua Zhang, An Li, Jingjun Zhang, Yanling Zhang
Pages: 573-580
Published online on: 13 November 2018

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miR‑494‑3p promotes the progression of endometrial cancer by regulating the PTEN/PI3K/AKT pathway

Lichao Zhu, Xiaoyan Wang, Tao Wang, Wenwen Zhu, Xinge Zhou
Pages: 581-588
Published online on: 13 November 2018

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Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Qing Luo, Xue Li, Lu Zhang, Fangyi Yao, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang, Junming Li
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CLCN7 and TCIRG1 mutations in a single family: Evidence for digenic inheritance of osteopetrosis

Yongjia Yang, Weihua Ye, Jihong Guo, Liu Zhao, Ming Tu, Yu Zheng, Liping Li
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Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC

Xiaochen Zhang, Liyuan Wei, Jun Li, Jing Zheng, Shirong Zhang, Jianying Zhou
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Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft‑vs.‑host disease in mice

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Magnetization transfer contrast MRI in GFP‑tagged live bacteria

Valeria Righi, Melissa Starkey, George Dai, Laurence G. Rahme, Aria A. Tzika
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MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2

Chunhua Zhang, Bo Wang, Ling Wu
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Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages

Yoo‑Jeong Song, Ahyeon Kim, Goon‑Tae Kim, Han Young Yu, Eun‑So Lee, Mi Jin Park, Young‑Jun Kim, Soon‑Mi Shim, Tae‑Sik Park
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Characterization of circRNA‑associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation

Yangyang Zhang, Xianting Ke, Jingjing Liu, Xiue Ma, Yi Liu, Dandan Liang, Luxin Wang, Changfa Guo, Yiwei Luo
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UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats

Bingju Yan, Jun Wang
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Involvement of endothelial nitric oxide synthase pathway in IGF‑1 protects endothelial progenitor cells against injury from oxidized LDLs Corrigendum in /10.3892/mmr.2020.11031

Hao Jing‑Wen, Guo‑Feng Liu, Li‑Zhi Xiao, Yong‑Gang Wu
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Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells

Wanzhen Jiao, Jiafu Ji, Fengjiao Li, Jianlian Guo, Yuanjie Zheng, Shangbin Li, Wenwen Xu
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Published online on: 09 November 2018

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Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway

Xiuzhen Hao, Jie Yuan, Huixiao Dong
Pages: 678-684
Published online on: 02 November 2018

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Long non‑coding RNA Fer‑1‑like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo

Xinyi Sun, Guoqi Zheng, Chunying Li, Chendi Liu
Pages: 685-692
Published online on: 07 November 2018

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MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma

Longkun Lv, Qiang Wang, Yucheng Yang, Honghai Ji
Pages: 693-702
Published online on: 01 November 2018

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IL‑18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF‑κB signaling

Fang Wang, Min Guan, Liting Wei, Hui Yan
Pages: 703-710
Published online on: 26 November 2018

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MicroRNA‑663 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells by directly targeting PAK4 Retraction in /10.3892/mmr.2023.12995

Yingying Liu, Dan Jiao, Zhen Tian
Pages: 711-718
Published online on: 13 November 2018

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MicroRNA‑584 directly targets CCND1 and inhibits cell proliferation and invasion in pancreatic cancer

Gang Chen, Ming Hu, Xiusheng Qu, Kaifeng Wang, Yikun Qu
Pages: 719-726
Published online on: 13 November 2018

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Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Caixia Li, Rong Chen, Caixia Jiang, Li Chen, Zhongping Cheng
Pages: 727-733
Published online on: 01 November 2018

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MicroRNA‑940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel‑like factor 9

Dongzi Zhang, Puheng Hao, Lin Jin, Yuangang Wang, Zhifeng Yan, Shuqiang Wu
Pages: 734-742
Published online on: 07 November 2018

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L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level

Rui Wang, Liuxin Wang, Caishun Zhang, Yan Zhang, Yuan Liu, Limin Song, Ruixia Ma, Jing Dong
Pages: 743-751
Published online on: 13 November 2018

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
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Article Number: 46
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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Article Number: 45
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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