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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2019 Volume 19 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Roles of the inflammasome in the gut‑liver axis (Review)

Junfeng Wang, Rui Dong, Shan Zheng
Pages: 3-14
Published online on: 20 November 2018

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Review Open Access

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

Martha Cristina Diaz‑Franco, Raul Franco‑Diaz de Leon, Jose Rafael Villafan‑Bernal
Pages: 15-22
Published online on: 05 November 2018

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Review

Molecular targets of curcumin in breast cancer (Review)

Xinqiang Song, Mu Zhang, Erqin Dai, Yuan Luo
Pages: 23-29
Published online on: 19 November 2018

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Article Open Access

Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis

Rongqiang Zhang, Xiaoli Yang, Jing Wang, Lixin Han, Aimin Yang, Jie Zhang, Dandan Zhang, Baorong Li, Zhaofang Li, Yongmin Xiong
Pages: 30-40
Published online on: 20 November 2018

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Article Open Access

Hyperoside decreases the apoptosis and autophagy rates of osteoblast MC3T3‑E1 cells by regulating TNF‑like weak inducer of apoptosis and the p38mitogen activated protein kinase pathway

Qing Zhang, Xiao‑Feng Zhang
Pages: 41-50
Published online on: 02 November 2018

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Article Open Access

Long‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse

Wanming Cui, Haolin Wang, Yu Cheng, Xiaorui Ma, Yu Lei, Xingxing Ruan, Lin Shi, Mei Lv
Pages: 51-58
Published online on: 05 November 2018

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Article Open Access

PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression

Xia Wang, Xu Liu, Yuan Ren, Ying Liu, Shuangyu Han, Jingkang Zhao, Xingchun Gou, Yuan He
Pages: 59-74
Published online on: 12 November 2018

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Article Open Access

PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis

Jie Wu, Sheng Xiao, Miaomiao Yuan, Qianyuan Li, Guangfen Xiao, Wei Wu, Yuexian Ouyang, Lihua Huang, Chenjiao Yao
Pages: 75-84
Published online on: 06 November 2018

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Article Open Access

Downregulation of NLRP2 inhibits HUVEC viability by inhibiting the MAPK signaling pathway

Xiaolu Zhang, Xinlei Lu, Limei Yu, Yufeng Gu, Fuzheng Qu
Pages: 85-92
Published online on: 05 November 2018

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Article Open Access

Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury Corrigendum in /10.3892/mmr.2019.10629

Peiyan Huang, Jun Gu, Junguo Wu, Lei Geng, Yang Hong, Siqun Wang , Minghai Wang
Pages: 93-102
Published online on: 21 November 2018

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Article Open Access

Potential functions of long non‑coding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells

Xiang Sun, Bo Jia, Xiao‑Ling Qiu, Hong‑Xing Chu, Zhao‑Qiang Zhang, Zhi‑Ping Wang, Jian‑Jiang Zhao
Pages: 103-114
Published online on: 20 November 2018

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Article Open Access

Integration of high‑throughput data of microRNA and mRNA expression profiles reveals novel insights into the mechanism of liver fibrosis

Yitong Zhang, Jing Liu, Yanyun Ma, Jingjie Wang, Jie Zhu, Jie Liu, Jun Zhang
Pages: 115-124
Published online on: 09 November 2018

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Article Open Access

Platelet‑derived growth factor D promotes the angiogenic capacity of endothelial progenitor cells

Jianbo Zhang, Haolong Zhang, Yikuan Chen, Jian Fu, Yu Lei, Jianming Sun, Bo Tang
Pages: 125-132
Published online on: 26 November 2018

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Article Open Access

Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo

Guixiang Tian, Xiue Sun, Jingkun Bai, Jinhua Dong, Bo Zhang, Zhiqin Gao, Jingliang Wu
Pages: 133-142
Published online on: 22 November 2018

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Article Open Access

Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis

Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui, Wenxia Meng, Wei Guo, Baoshan Wang
Pages: 143-154
Published online on: 09 November 2018

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Article Open Access

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity

Meiying Feng, Nannan Dang, Yinshan Bai, Hengxi Wei, Li Meng, Kai Wang, Zhihong Zhao, Yun Chen, Fenglei Gao, Zhilin Chen, Li Li, Shouquan Zhang
Pages: 155-164
Published online on: 20 November 2018

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Article Open Access

Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells

Yun‑Qian Guan, Chun‑Song Zhao, Hai‑Qiang Zou, Xiao‑Ming Yan, Lu‑Lu Luo, Jia‑Lin Wu, Xiaobo Li, Yu Alex Zhang
Pages: 165-176
Published online on: 19 November 2018

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Article Open Access

Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways

Simeng Wu, Yajun Wang, Zhe Yuan, Siliang Wang, Hongmei Du, Xue Liu, Qiushi Wang, Xike Zhu
Pages: 177-186
Published online on: 19 November 2018

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Article Open Access

Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder

Jun Lu, Ling‑Feng Zhu, Yuan‑Ming Cai, Hui‑Yue Dong, Ling Zhu, Jian‑Ming Tan
Pages: 187-194
Published online on: 12 November 2018

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Article Open Access

Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone

Lang Gan, Shuguang Pan, Jinchi Cui, Jie Bai, Peng Jiang, Yu He
Pages: 195-204
Published online on: 15 November 2018

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Article Open Access

Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Pages: 205-212
Published online on: 21 November 2018

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Article Open Access

MG132 selectively upregulates MICB through the DNA damage response pathway in A549 cells

Dan Luo, Xi‑Wen Dong, Bing Yan, Mei Liu, Tian‑Hui Xue, Hui Liu, Jun‑Hao You, Fang Li, Zi‑Ling Wang, Zhi‑Nan Chen
Pages: 213-220
Published online on: 20 November 2018

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Article Open Access

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation

Jingxiao Lu, Yang Su, Xianguo Chen, Yuan Chen, Pengcheng Luo, Fangyou Lin, Jie Zhang
Pages: 221-230
Published online on: 21 November 2018

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Article Open Access

P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling

Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xia
Pages: 231-237
Published online on: 15 November 2018

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Article Open Access

Establishment of microRNA, transcript and protein regulatory networks in Alport syndrome induced pluripotent stem cells

Wenbiao Chen, Donge Tang, Yong Dai, Hongyan Diao
Pages: 238-250
Published online on: 20 November 2018

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Article Open Access

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling

Qinchen Cao, Xinxin Wang, Yonggang Shi, Mingzhi Zhang, Jing Yang, Meilian Dong, Yin Mi, Zhigang Zhang, Ke Liu, Li Jiang, Na Wang, Ping Wang
Pages: 251-261
Published online on: 13 November 2018

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Article Open Access

Hepatitis B virus core protein dimer‑dimer interface is critical for viral replication

Chang‑Long Zheng, Yong‑Mei Fu, Zhan‑Xue Xu, Yong Zou, Kai Deng
Pages: 262-270
Published online on: 02 November 2018

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Article Open Access

Hypoxia‑induced miR‑210 contributes to apoptosis of mouse spermatocyte GC‑2 cells by targeting Kruppel‑like factor 7

Jin‑Xing Lv, Jian Zhou, Rui‑Qing Tong, Bin Wang, Xue‑Lei Chen, Yan‑Yan Zhuang, Fei Xia, Xue‑Dong Wei
Pages: 271-279
Published online on: 12 November 2018

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Article Open Access

UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

Xuemei Fan, Jianfa Jiang, Zhiqiang Huang, Jumei Gong, Yiming Wang, Wei Xue, Yan Deng, Yanfang Wang, Tingping Zheng, Aijun Sun, Guoan Luo
Pages: 280-292
Published online on: 12 November 2018

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Article Open Access

The role of E2F8 in the human placenta

Masako Mizuno, Rika Miki, Yoshinori Moriyama, Takafumi Ushida, Kenji Imai, Kaoru Niimi, Tomoko Nakano, Hiroyuki Tsuda, Seiji Sumigama, Eiko Yamamoto, Takeshi Senga, Akira Iwase, Fumitaka Kikkawa, Tomomi Kotani
Pages: 293-301
Published online on: 01 November 2018

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Article Open Access

Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

Hua Li, Zijie Cheng, Yuanyuan Tang, Mengwen Feng, Anwen Yin, Hao Zhang, Jia Xu, Qijun Zhang, Jinsong Zhang, Lingmei Qian
Pages: 302-308
Published online on: 13 November 2018

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Article Open Access

CagA increases DNA methylation and decreases PTEN expression in human gastric cancer

Baogui Zhang, Xiaobei Zhang, Meng Jin, Lei Hu, Mingde Zang, Weilong Qiu, Shouqi Wang, Bingya Liu, Shiqi Liu, Dongli Guo
Pages: 309-319
Published online on: 13 November 2018

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Article Open Access

Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis

Bingqian Wang, Wenna Li, Hezhi Fang, Huaibin Zhou
Pages: 320-326
Published online on: 02 November 2018

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Article Open Access

c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats

Geng‑Qiang Ling, Xian‑Feng Li, Xu‑Hui Lei, Zhen‑Yu Wang, Dong‑Ying Ma, Yue‑Na Wang, Wei Ye
Pages: 327-337
Published online on: 09 November 2018

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Article Open Access

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat Schwann cells in vitro

Qing Li, Yang Jiao, Yang Yu, Guolin Wang, Yonghao Yu
Pages: 338-344
Published online on: 08 November 2018

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Article Open Access

MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines

Nevim Aygun, Oguz Altungoz
Pages: 345-361
Published online on: 22 November 2018

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Article Open Access

Identification of key candidate genes and miRNA‑mRNA target pairs in chronic lymphocytic leukemia by integrated bioinformatics analysis

Chundi Gao, Chao Zhou, Jing Zhuang, Lijuan Liu, Junyu Wei, Cun Liu, Huayao Li, Changgang Sun
Pages: 362-374
Published online on: 09 November 2018

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Article Open Access

Enhanced adhesion and proliferation of bone marrow mesenchymal stem cells on β‑tricalcium phosphate modified by an affinity peptide

Guozong Wang, Zhentao Man, Hua Xin, Yi Li, Changshun Wu, Shui Sun
Pages: 375-381
Published online on: 13 November 2018

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Article Open Access

Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll‑like receptor‑4‑NADPH oxidase 4 signaling pathway

Zhi‑Peng You, Meng‑Jia Yu, Yu‑Lan Zhang, Ke Shi
Pages: 382-390
Published online on: 08 November 2018

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Article Open Access

Genome‑wide DNA methylation analysis of uterosacral ligaments in women with pelvic organ prolapse Corrigendum in /10.3892/mmr.2019.9852

Lifang Zhang, Ping Zheng, Aihong Duan, Yan Hao, Chang Lu, Dan Lu
Pages: 391-399
Published online on: 13 November 2018

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Article Open Access

Visfatin is regulated by interleukin‑6 and affected by the PPAR‑γ pathway in BeWo cells

Yanhong Zhang, Yan Huo, Wenhui He, Suxin Liu, Hongyan Li, Li Li
Pages: 400-406
Published online on: 20 November 2018

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Article Open Access

Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

Guozong Wang, Zhentao Man, Nianping Zhang, Hua Xin, Yi Li, Tiantong Sun, Shui Sun
Pages: 407-413
Published online on: 05 November 2018

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Article Open Access

Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway

Jin Yi, Ruohui Tang, Jing Yang, Yueqi Chen, Jun Fei
Pages: 414-422
Published online on: 15 November 2018

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Article Open Access

Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats

Qiang Jia, Rui Yang, Xiao‑Fen Liu, Shan‑Feng Ma, Lei Wang
Pages: 423-431
Published online on: 09 November 2018

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Article Open Access

Rosuvastatin protects against oxidized low‑density lipoprotein‑induced endothelial cell injury of atherosclerosis in vitro

Jianan Geng, Huali Xu, Xiaofeng Yu, Guoliang Xu, Hongyan Cao, Guangzhu Lin, Dayun Sui
Pages: 432-440
Published online on: 19 November 2018

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Article Open Access

Potential four‑miRNA signature associated with T stage and prognosis of patients with pancreatic ductal adenocarcinoma identified by co‑expression analysis

Lukuan You, Jinliang Wang, Fan Zhang, Jing Zhang, Haitao Tao, Xuan Zheng, Yi Hu
Pages: 441-451
Published online on: 19 November 2018

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Article Open Access

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

Jin Ju Park, Ji Eun Kim, Woo Bin Yun, Mi Rim Lee, Jun Young Choi, Bo Ram Song, Hong Joo Son, Yong Lim, Hyun‑Gu Kang, Beum Soo An, Seung Yun Yang, Sung Baek Seo, Dae Youn Hwang
Pages: 452-460
Published online on: 19 November 2018

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Article Open Access

(R)‑dehydroxyabscisic alcohol β‑D‑apiofuranosyl‑(1ˮ→6ʼ)‑β‑D‑glucopyranoside enhances the osteoblastic differentiation of ST2 cells via the BMP/WNT pathways

Yadong Liu, Tao Yang, Ting Chen, Jun Hao, Yu Gai, Weiguo Zhang
Pages: 461-467
Published online on: 23 November 2018

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Article Open Access

MEK inhibition prevents TGF‑β1‑induced myofibroblast transdifferentiation in human tenon fibroblasts

Jiamin Wen, Xianchai Lin, Wuyou Gao, Bo Qu, Yunlan Ling, Rongjiao Liu, Minbin Yu
Pages: 468-476
Published online on: 20 November 2018

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Article Open Access

Meta‑analysis of current chemotherapy regimens in advanced pancreatic cancer to prolong survival and reduce treatment‑associated toxicities

Jie Chen, Linli Chen, Jianping Yu, Yanmei Xu, Xiaohui Wang, Ziqian Zeng, Ning Liu, Fan Xu, Shu Yang
Pages: 477-489
Published online on: 09 November 2018

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Article Open Access

Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice

Yuzhu Cheng, Zhanlun Ou, Qingguo Li, Juan Yang, Min Hu, Yubin Zhou, Xiaodong Zhuang, Zhenyu Jason Zhang, Shixia Guan
Pages: 490-498
Published online on: 23 November 2018

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Article Open Access

Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy

Qian Wang, Yuxin Sun, Tianshu Li, Lianqin Liu, Yunxia Zhao, Liyuan Li, Ling Zhang, Yan Meng
Pages: 499-507
Published online on: 21 November 2018

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Article Open Access

miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2

Xiaohe Chen, Shouhang Yang, Jue Zeng, Ming Chen
Pages: 508-514
Published online on: 21 November 2018

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Article

SKA2 mediates invasion and metastasis in human breast cancer via EMT

Zhouhui Ren, Tong Yang, Pingping Zhang, Kaitai Liu, Weihong Liu, Ping Wang
Pages: 515-523
Published online on: 02 November 2018

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Article

HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma

Li Dong, Liying Xue, Cuiying Zhang, Hui Li, Zhihui Cai, Ruifang Guo
Pages: 524-532
Published online on: 19 November 2018

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Article

Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5

Yueling Wang, Aijun Jia, Wenjuan Ma
Pages: 533-540
Published online on: 26 November 2018

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Article

Knockdown of P120 catenin aggravates endothelial injury under an impinging flow by inducing breakdown of adherens junctions

Jian‑Lan Zhao, Zhi‑Peng Xiao, Nian‑Zu Yu, Jin‑Wen Jiang, Mei‑Hua Li
Pages: 541-548
Published online on: 13 November 2018

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Article

Dynamic Nestin expression during hair follicle maturation and the normal hair cycle

Ruosi Chen, Yong Miao, Zhiqi Hu
Pages: 549-554
Published online on: 26 November 2018

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Article

Nicotinamide induces liver regeneration and improves liver function by activating SIRT1

Hai‑Feng Wan, Jia‑Xin Li, Hao‑Tian Liao, Ming‑Heng Liao, Lin Luo, Lin Xu, Ke‑Fei Yuan, Yong Zeng
Pages: 555-562
Published online on: 22 November 2018

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Article

(+)‑pinoresinol‑O‑β‑D‑glucopyranoside from Eucommia ulmoides Oliver and its anti‑inflammatory and antiviral effects against influenza A (H1N1) virus infection

Jing Li, Xiaoli Liang, Beixian Zhou, Xiaowei Chen, Peifang Xie, Haiming Jiang, Zhihong Jiang, Zifeng Yang, Xiping Pan
Pages: 563-572
Published online on: 26 November 2018

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Article

Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway

Junyan Wu, Cong Zhang, Chuanjun Liu, Aihua Zhang, An Li, Jingjun Zhang, Yanling Zhang
Pages: 573-580
Published online on: 13 November 2018

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Article

miR‑494‑3p promotes the progression of endometrial cancer by regulating the PTEN/PI3K/AKT pathway

Lichao Zhu, Xiaoyan Wang, Tao Wang, Wenwen Zhu, Xinge Zhou
Pages: 581-588
Published online on: 13 November 2018

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Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Qing Luo, Xue Li, Lu Zhang, Fangyi Yao, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang, Junming Li
Pages: 589-594
Published online on: 08 November 2018

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CLCN7 and TCIRG1 mutations in a single family: Evidence for digenic inheritance of osteopetrosis

Yongjia Yang, Weihua Ye, Jihong Guo, Liu Zhao, Ming Tu, Yu Zheng, Liping Li
Pages: 595-600
Published online on: 13 November 2018

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Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC

Xiaochen Zhang, Liyuan Wei, Jun Li, Jing Zheng, Shirong Zhang, Jianying Zhou
Pages: 601-608
Published online on: 21 November 2018

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Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft‑vs.‑host disease in mice

Kyung‑Ah Cho, Yu‑Hee Kim, Minhwa Park, Hye Ji Kim, So‑Youn Woo, Joo‑Won Park, Kyung‑Ha Ryu
Pages: 609-616
Published online on: 13 November 2018

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Magnetization transfer contrast MRI in GFP‑tagged live bacteria

Valeria Righi, Melissa Starkey, George Dai, Laurence G. Rahme, Aria A. Tzika
Pages: 617-621
Published online on: 19 November 2018

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Article

MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2

Chunhua Zhang, Bo Wang, Ling Wu
Pages: 622-628
Published online on: 12 November 2018

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Article

Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages

Yoo‑Jeong Song, Ahyeon Kim, Goon‑Tae Kim, Han Young Yu, Eun‑So Lee, Mi Jin Park, Young‑Jun Kim, Soon‑Mi Shim, Tae‑Sik Park
Pages: 629-637
Published online on: 20 November 2018

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Characterization of circRNA‑associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation

Yangyang Zhang, Xianting Ke, Jingjing Liu, Xiue Ma, Yi Liu, Dandan Liang, Luxin Wang, Changfa Guo, Yiwei Luo
Pages: 638-650
Published online on: 26 November 2018

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Article

UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats

Bingju Yan, Jun Wang
Pages: 651-659
Published online on: 26 November 2018

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Article

Involvement of endothelial nitric oxide synthase pathway in IGF‑1 protects endothelial progenitor cells against injury from oxidized LDLs Corrigendum in /10.3892/mmr.2020.11031

Hao Jing‑Wen, Guo‑Feng Liu, Li‑Zhi Xiao, Yong‑Gang Wu
Pages: 660-666
Published online on: 08 November 2018

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Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells

Wanzhen Jiao, Jiafu Ji, Fengjiao Li, Jianlian Guo, Yuanjie Zheng, Shangbin Li, Wenwen Xu
Pages: 667-677
Published online on: 09 November 2018

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Article

Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway

Xiuzhen Hao, Jie Yuan, Huixiao Dong
Pages: 678-684
Published online on: 02 November 2018

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Article

Long non‑coding RNA Fer‑1‑like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo

Xinyi Sun, Guoqi Zheng, Chunying Li, Chendi Liu
Pages: 685-692
Published online on: 07 November 2018

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MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma

Longkun Lv, Qiang Wang, Yucheng Yang, Honghai Ji
Pages: 693-702
Published online on: 01 November 2018

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Article

IL‑18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF‑κB signaling

Fang Wang, Min Guan, Liting Wei, Hui Yan
Pages: 703-710
Published online on: 26 November 2018

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MicroRNA‑663 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells by directly targeting PAK4 Retraction in /10.3892/mmr.2023.12995

Yingying Liu, Dan Jiao, Zhen Tian
Pages: 711-718
Published online on: 13 November 2018

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MicroRNA‑584 directly targets CCND1 and inhibits cell proliferation and invasion in pancreatic cancer

Gang Chen, Ming Hu, Xiusheng Qu, Kaifeng Wang, Yikun Qu
Pages: 719-726
Published online on: 13 November 2018

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Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Caixia Li, Rong Chen, Caixia Jiang, Li Chen, Zhongping Cheng
Pages: 727-733
Published online on: 01 November 2018

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MicroRNA‑940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel‑like factor 9

Dongzi Zhang, Puheng Hao, Lin Jin, Yuangang Wang, Zhifeng Yan, Shuqiang Wu
Pages: 734-742
Published online on: 07 November 2018

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L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level

Rui Wang, Liuxin Wang, Caishun Zhang, Yan Zhang, Yuan Liu, Limin Song, Ruixia Ma, Jing Dong
Pages: 743-751
Published online on: 13 November 2018

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Journal Cover
July-2026 Volume 34 Issue 1

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Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Regulatory mechanisms and therapeutic potential of N6-methyladenosine modification in retinal diseases (Review)

Wenyao Zhang, Jinying Chen, Jingxiang Zhong
Article Number: 213
Published online on: 29 May 2026

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Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non‑coding RNAs in cutaneous fibrosis (Review)

Jinshun Li, Weiyun Liu, Jin Yang, Yanan Li
Article Number: 212
Published online on: 29 May 2026

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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review)

Xiaoyan Xue, Yongchang Lai, Shasha Song, Liping Wu, Lifang Wang
Article Number: 211
Published online on: 29 May 2026

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Retraction Open Access

[Retracted] Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells

Yuan Zeng, Ying Yang
Article Number: 210
Published online on: 27 May 2026

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FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression

Linyu Jin, Jing Zhang, Wenjing Wang, Nan Zhang, Yang Liu, Alin Tian, Weiwei Yin, Yongle Qiu
Article Number: 209
Published online on: 25 May 2026

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Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)

Songhua Nan, Chaojie Peng, Xue Meng, Jingnan Jia, Fangfang Zhao, Yinglin Cui
Article Number: 208
Published online on: 22 May 2026

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Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review)

Hailing Zhang, Yongji Li, Yuan Liu, Danyi Feng, Letao Zhao, Ran Chen, Xiwu Zhang, Jinjin Dou
Article Number: 207
Published online on: 22 May 2026

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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review)

Yadi Ju, Xiaodan Chong, Weichen Ning, Yan Shi, Yangyang Li, Yihai Shi
Article Number: 206
Published online on: 22 May 2026

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Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review)

Chengzhi Cong, Yuan Wang, Jian Liu, Chao Jin
Article Number: 205
Published online on: 21 May 2026

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Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

Fatima Zohra Attouahri, Imane Chaoui, Abdelilah Laraqui, Mohamed Rida Tagajdid, Mohammed Oukabli, Mohammed El Marjany, Meriem Khyatti, Mohammed Attaleb, Mouna Ababou, Khalid Ennibi, Khaoula Errafii, Mohammed El Mzibri
Article Number: 204
Published online on: 21 May 2026

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Epigenetic research methods and animal models for intervertebral disc degeneration (Review)

Xinliang Cui, Li Zeng, Wei Zhang, Leimin Xi, Rui Wang, Diff Jia, Safa, Haoyu Feng, Huidong Jia
Article Number: 203
Published online on: 21 May 2026

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ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression

Jingyi Wang, Bin Yang, Shengzu Peng, Bin Yang
Article Number: 202
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] MicroRNA‑1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post‑​transcriptional suppression of Ihh expression  

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Article Number: 201
Published online on: 20 May 2026

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Estrogen deficiency as a common driver and integrative mechanism in osteoporosis‑osteoarthritis comorbidity (Review)

Jian Cheng, Xiaodong Wu, Lu Zhao, Shuai Jiang, Wenjie Zhao, Weishuai Zhang
Article Number: 200
Published online on: 20 May 2026

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Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review)

Qin Jiang, Yi Gong, Mimi Zhai, Tenglong Tang, Sushun Liu
Article Number: 199
Published online on: 20 May 2026

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m6A modification in skeletal system diseases (Review)

Xi Xie, Chen Li, Haotian Zheng, Guang Gan, Xi Gao
Article Number: 198
Published online on: 19 May 2026

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Dynamic regulation of the ‘mitochondria‑immune axis’ in myocardial infarction: Molecular mechanisms driving macrophage polarization through energy metabolism disorders (Review)

Yu Zhang, Hao Feng, Qin Wu, Shuxian Yang, Yundong Jiang, Houping Xu, Li Dong, Xiaolin Li, Hui Chen, Gang Luo
Article Number: 197
Published online on: 19 May 2026

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[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway

Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
Article Number: 196
Published online on: 18 May 2026

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Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review)

Changmei Wu, Jinjin Dou, Xiwu Zhang
Article Number: 195
Published online on: 18 May 2026

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Article Open Access

NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome

Jiajun Xie, Huina Zhang, Wenyue Shen, Juan Ye
Article Number: 194
Published online on: 18 May 2026

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POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review)

Haotian Wu, Xianglin Dong
Article Number: 193
Published online on: 15 May 2026

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Emerging role of DYRK1A as a target in cardiovascular diseases (Review)

Liqing Yu, Qionghong Cheng, Jun Wu
Article Number: 192
Published online on: 15 May 2026

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[Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Article Number: 191
Published online on: 05 May 2026

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Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review)

Jingheng Song, Hongguo Cui, Peisen Yang, Yankai Xu, Yuanyuan Liu, Gang Zhang, Yangyang Liu, Aimin Tian, Jizhong Che, Hui Sun, Zhengchao Zhang
Article Number: 190
Published online on: 04 May 2026

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Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

Juan Li, Siqin Zhou, Yu Wang, Guanghan Ou, Danli Yang, Liwen Shen
Article Number: 189
Published online on: 04 May 2026

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Applications of humanized mice in Mycobacterium tuberculosis infections (Review)

Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, Haiyan Yang
Article Number: 188
Published online on: 04 May 2026

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Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review)

Jiandong Hu, Mengli Jin, Zhihua Cao, Binbin Zheng, Yuan Zheng, Hao Shen
Article Number: 187
Published online on: 04 May 2026

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Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review)

Shilin Zhang, Zhenhua Li, Li Fu
Article Number: 186
Published online on: 04 May 2026

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Effects of ALDH2 gene expression on the oxidative stress‑mediated NF‑κB/mTOR pathway in ketamine‑induced cystitis

Xiao Jian Xi, Yong Yao, Peng Gu, Min Hao Zhang
Article Number: 185
Published online on: 04 May 2026

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[Retracted] Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Junchao Yao, Kebin Zheng, Xiang Zhang
Article Number: 184
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Article Open Access

Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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Review Open Access

SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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