Open Access

EVI‑1 acts as an oncogene and positively regulates calreticulin in breast cancer

Retraction in: /10.3892/mmr.2023.13112

  • Authors:
    • Lei Wu
    • Tianyi Wang
    • Dongning He
    • Xiaoxi Li
    • Youhong Jiang
  • View Affiliations

  • Published online on: December 24, 2018     https://doi.org/10.3892/mmr.2018.9796
  • Pages: 1645-1653
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ecotropic viral integration site‑1 (EVI‑1) is an important transcription factor involved in oncogenesis. Aberrant EVI‑1 expression has been reported to be a characteristic of multiple types of malignancies; however, very little is known about how EVI‑1 regulates breast cancer. Current knowledge of how target genes mediate the biological function of EVI‑1 remains limited. In the present study, overexpression of EVI‑1 promoted cell proliferation, migration, and invasion, and inhibited apoptosis in breast cancer. By contrast, silencing of EVI‑1 inhibited cell proliferation, migration and invasion, and enhanced apoptosis in breast cancer. In addition, the results also revealed that the aberrant expression of EVI‑1 regulates genes associated with the apoptotic pathway in breast cancer. Furthermore, EVI‑1 was also likely to target the promoter region of calreticulin (CRT) in vitro. It was concluded that EVI‑1 can affect epithelial mesenchymal transition‑associated genes by regulating the expression of CRT in breast cancer. The results revealed that EVI‑1 may be a potential effective therapeutic target in breast cancer.
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March-2019
Volume 19 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wu L, Wang T, He D, Li X and Jiang Y: EVI‑1 acts as an oncogene and positively regulates calreticulin in breast cancer Retraction in /10.3892/mmr.2023.13112. Mol Med Rep 19: 1645-1653, 2019
APA
Wu, L., Wang, T., He, D., Li, X., & Jiang, Y. (2019). EVI‑1 acts as an oncogene and positively regulates calreticulin in breast cancer Retraction in /10.3892/mmr.2023.13112. Molecular Medicine Reports, 19, 1645-1653. https://doi.org/10.3892/mmr.2018.9796
MLA
Wu, L., Wang, T., He, D., Li, X., Jiang, Y."EVI‑1 acts as an oncogene and positively regulates calreticulin in breast cancer Retraction in /10.3892/mmr.2023.13112". Molecular Medicine Reports 19.3 (2019): 1645-1653.
Chicago
Wu, L., Wang, T., He, D., Li, X., Jiang, Y."EVI‑1 acts as an oncogene and positively regulates calreticulin in breast cancer Retraction in /10.3892/mmr.2023.13112". Molecular Medicine Reports 19, no. 3 (2019): 1645-1653. https://doi.org/10.3892/mmr.2018.9796