Open Access

Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus

  • Authors:
    • Chong Zhang
    • Si‑Jing Fan
    • An‑Bang Sun
    • Zhen‑Zhen Liu
    • Lian Liu
  • View Affiliations

  • Published online on: March 29, 2019     https://doi.org/10.3892/mmr.2019.10105
  • Pages: 4185-4194
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE‑induced depression‑like behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant rats twice daily from gestational day (GD) 9 to 20. In adolescent offspring, PNE significantly increased immobility time and decreased the sucrose preference in female rats. The numbers of hippocampal neurons declined in the CA3 and DG regions. Steroidogenic acute regulatory protein (StAR) expression was suppressed in female rats. In fetal offspring, the neuronal numbers of CA3 regions in PNE female fetal hippocampal were significantly decreased, accompanied by the enhanced content of corticosterone and StAR expression. These data indicated that PNE induced depression‑like behavior in adolescent female rats via the regulation of neurosteroid levels in the hippocampus.
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May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang C, Fan SJ, Sun AB, Liu ZZ and Liu L: Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus. Mol Med Rep 19: 4185-4194, 2019
APA
Zhang, C., Fan, S., Sun, A., Liu, Z., & Liu, L. (2019). Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus. Molecular Medicine Reports, 19, 4185-4194. https://doi.org/10.3892/mmr.2019.10105
MLA
Zhang, C., Fan, S., Sun, A., Liu, Z., Liu, L."Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus". Molecular Medicine Reports 19.5 (2019): 4185-4194.
Chicago
Zhang, C., Fan, S., Sun, A., Liu, Z., Liu, L."Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus". Molecular Medicine Reports 19, no. 5 (2019): 4185-4194. https://doi.org/10.3892/mmr.2019.10105