Asymmetric synthesis of anticancer β-lactams via Staudinger reaction

  • Authors:
    • Bimal K. Banik
    • Susanta Samajdar
    • Frederick F. Becker
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  • Published online on: March 1, 2010     https://doi.org/10.3892/mmr_00000259
  • Pages: 319-321
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Abstract

This study describes the symmetric synthesis of novel β-lactams derived from chrysene directed towards their SAR, as well as their biological activities against several cancer cell lines in vitro. To our knowledge, this is the first report on the synthesis and biological evaluation of optically active anticancer β-lactams. That these anticancer effects are not uniform against all tumor lines suggests that the target of the action of these compounds is highly specific.

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March 2010
Volume 3 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Banik, B.K., Samajdar, S., & Becker, F.F. (2010). Asymmetric synthesis of anticancer β-lactams via Staudinger reaction . Molecular Medicine Reports, 3, 319-321. https://doi.org/10.3892/mmr_00000259
MLA
Banik, B. K., Samajdar, S., Becker, F. F."Asymmetric synthesis of anticancer β-lactams via Staudinger reaction ". Molecular Medicine Reports 3.2 (2010): 319-321.
Chicago
Banik, B. K., Samajdar, S., Becker, F. F."Asymmetric synthesis of anticancer β-lactams via Staudinger reaction ". Molecular Medicine Reports 3, no. 2 (2010): 319-321. https://doi.org/10.3892/mmr_00000259