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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats

  • Authors:
    • Pengli Zhu
    • Hong Lin
    • Chengai Sun
    • Fan Lin
    • Huizhen Yu
    • Xiuping Zhuo
    • Chanjuan Zhou
    • Zhisheng Deng

  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
  • Pages: 655-662
    |
    Published online on: December 19, 2011
       https://doi.org/10.3892/mmr.2011.717
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Abstract

The aim of this study was to investigate the protective effects of telmisartan and/or pyridoxamine on spontaneously hypertensive rats (SHRs). Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end products (AGEs), superoxide dismutase (SOD), malonaldehyde and the level of 24-h urinary albumin were measured. Morphological changes in renal tissues were observed under light (H&E or Masson's trichrome) and transmission electron microscopy. Expression of NF-κBp65 and p-ERK1/2 in renal tissue was detected by immunohistochemistry. Expression of receptors for advanced glycation end products (RAGE) and TGF-β in the renal cortex was investigated by western blotting. We found that early renal structural and functional damage was alleviated in the three intervention groups. SOD activity was significantly elevated in the P and TP groups (P<0.05) compared to that in the T group. Of note, both the positive expression of NF-κBp65 (P<0.01 vs. the T and P groups) and p-ERK1/2 (P<0.05 vs. the P group) was lowest in the TP group. Our results suggest that the combined use of telmisartan and pyridoxamine is superior to the single use of either drug on renoprotection, which may result from the alleviation of oxidative stress and the reduction of NF-κBp65 and p-ERK1/2 activation.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu P, Lin H, Sun C, Lin F, Yu H, Zhuo X, Zhou C and Deng Z: Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats. Mol Med Rep 5: 655-662, 2012.
APA
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X. ... Deng, Z. (2012). Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats. Molecular Medicine Reports, 5, 655-662. https://doi.org/10.3892/mmr.2011.717
MLA
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X., Zhou, C., Deng, Z."Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats". Molecular Medicine Reports 5.3 (2012): 655-662.
Chicago
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X., Zhou, C., Deng, Z."Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats". Molecular Medicine Reports 5, no. 3 (2012): 655-662. https://doi.org/10.3892/mmr.2011.717
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu P, Lin H, Sun C, Lin F, Yu H, Zhuo X, Zhou C and Deng Z: Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats. Mol Med Rep 5: 655-662, 2012.
APA
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X. ... Deng, Z. (2012). Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats. Molecular Medicine Reports, 5, 655-662. https://doi.org/10.3892/mmr.2011.717
MLA
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X., Zhou, C., Deng, Z."Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats". Molecular Medicine Reports 5.3 (2012): 655-662.
Chicago
Zhu, P., Lin, H., Sun, C., Lin, F., Yu, H., Zhuo, X., Zhou, C., Deng, Z."Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats". Molecular Medicine Reports 5, no. 3 (2012): 655-662. https://doi.org/10.3892/mmr.2011.717
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