Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract

  • Authors:
    • Yoon-Young Sung
    • Won-Kyung Yang
    • Ho Kyoung Kim
  • View Affiliations

  • Published online on: December 22, 2011     https://doi.org/10.3892/mmr.2011.735
  • Pages: 721-724
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Abstract

Litchi chinensis Sonn. (lychee), which belongs to the family of Sapindaceae, is a subtropical evergreen tree that is cultivated throughout Southeast Asia, particularly in China. Litchi chinensis has been reported to have anti-inflammatory, antioxidant and antidiabetic activities. However, the antiplatelet and anticoagulant effects of Litchi chinensis have not been reported previously. In this study, we investigated the effects of a 70% ethanol extract from Litchi chinensis (LCE) on platelet aggregation, coagulation and fibrinolysis. LCE dose-dependently inhibited collagen- and ADP-induced platelet aggregation in rat platelet-rich plasma. LCE at 4 mg/ml had a maximal inhibitory effect on platelet aggregation. In particular, the LCE 4 mg/ml-treated group showed almost complete inhibition in the collagen-induced platelet aggregation assay. It also significantly prolonged coagulation times, such as the activated partial thromboplastin and prothrombin time, in rat platelet-poor plasma. We also investigated the fibrinolytic effects of LCE using the fibrin plate assay. LCE increased fibrinolytic activity in a dose-dependent manner. These results demonstrated the antithrombotic effects of LCE and suggest that Litchi chinensis may be a new natural source for the development of antiplatelet, anticoagulant and thrombolytic therapeutics for thrombotic and cardiovascular diseases.

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March 2012
Volume 5 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Sung, Y., Yang, W., & Kim, H. (2012). Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract. Molecular Medicine Reports, 5, 721-724. https://doi.org/10.3892/mmr.2011.735
MLA
Sung, Y., Yang, W., Kim, H."Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract". Molecular Medicine Reports 5.3 (2012): 721-724.
Chicago
Sung, Y., Yang, W., Kim, H."Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract". Molecular Medicine Reports 5, no. 3 (2012): 721-724. https://doi.org/10.3892/mmr.2011.735