A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

Iwamuro,Masaya; Okada,Hiroyuki; Kawano,Seiji; Shiode,Junji; Takenaka,Ryuta; Imagawa,Atsushi; Inaba,Tomoki; Suzuki,Seiyu; Nishimura,Mamoru; Mizuno,Motowo; Araki,Masashi; Mannami,Tomohiko; Ueki,Toru; Kobashi,Haruhiko; Fukatsu,Haruka; Tanaka,Shouichi; Omoto,Akiyoshi; Kawai,Yoshinari; Kitagawa,Takashi; Toyokawa,Tatsuya; Takata,Katsuyoshi; Yoshino,Tadashi; Takaki,Akinobu; Yamamoto,Kazuhide

doi:10.3892/ol.2015.3251

A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

Authors:
- Masaya Iwamuro
- Hiroyuki Okada
- Seiji Kawano
- Junji Shiode
- Ryuta Takenaka
- Atsushi Imagawa
- Tomoki Inaba
- Seiyu Suzuki
- Mamoru Nishimura
- Motowo Mizuno
- Masashi Araki
- Tomohiko Mannami
- Toru Ueki
- Haruhiko Kobashi
- Haruka Fukatsu
- Shouichi Tanaka
- Akiyoshi Omoto
- Yoshinari Kawai
- Takashi Kitagawa
- Tatsuya Toyokawa
- Katsuyoshi Takata
- Tadashi Yoshino
- Akinobu Takaki
- Kazuhide Yamamoto
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Affiliations: Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Endoscopy, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama 700‑8511, Japan, Department of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama 708‑0841, Japan, Department of Gastroenterology, Mitoyo General Hospital, Kanonji 769‑1695, Japan, Department of Gastroenterology, Kagawa Prefectural Central Hospital, Takamatsu 760‑8557, Japan, Department of Internal Medicine, Sumitomo Besshi Hospital, Niihama 792‑8543, Japan, Department of Internal Medicine, Okayama City Hospital, Okayama 700‑8557, Japan, Department of Internal Medicine, Hiroshima City Hospital, Hiroshima 730‑8518, Japan, Department of Internal Medicine, Kagawa Rosai Hospital, Marugame 763‑8502, Japan, Department of Internal Medicine, Chugoku Central Hospital, Fukuyama 720‑0001, Japan, Department of Internal Medicine, Fukuyama City Hospital, Fukuyama 721‑8511, Japan, Department of Hepatology, Japanese Red Cross Okayama Hospital, Okayama 700‑8607, Japan, Department of Internal Medicine, St. Mary's Hospital, Himeji 670‑0801, Japan, Department of Gastroenterology, Iwakuni Clinical Center, Iwakuni 740‑8510, Japan, Department of Internal Medicine, Ako Central Hospital, Ako 678‑0241, Japan, Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi 722‑8503, Japan, Department of Surgery, Kitagawa Hospital, Okayama 709‑0497, Japan, Department of Gastroenterology, Fukuyama Medical Center, Fukuyama 720‑8520, Japan, Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
Published online on: May 20, 2015 https://doi.org/10.3892/ol.2015.3251
Pages: 131-136
Copyright: © Iwamuro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The importance of enteroscopy examinations to investigate the entire length of the small intestines has been emphasized in follicular lymphoma patients with intestinal involvement. The aim of the present study was to determine the current state of enteroscopy examinations, including the performance rate, and the prevalence of small intestinal lesions in a patient population in Japan. A retrospective multicenter survey of 17 institutions collected the case information of 110 follicular lymphoma patients with gastrointestinal involvement. The results of the enteroscopy examinations were reviewed, and in order to identify potential factors affecting the performance rate of enteroscopy, patient gender, age at lymphoma diagnosis, histopathological grade, clinical stage, the date of the initial diagnosis and the annual volume of enteroscopy at the institution were compared between the patients who underwent one or more enteroscopy procedures and the patients who did not undergo enteroscopy. A total of 34 patients (30.9%) underwent enteroscopy, and 24 of these (70.6%) presented with involvement in the jejunum and/or ileum. It was found that more patients diagnosed in recent years and more patients treated at an ultra‑high volume institution (≥101 enteroscopy examinations/year) underwent an enteroscopy. In conclusion, although the prevalence of small intestinal lesions was high (70.6%) in the follicular lymphoma patients presenting with intestinal involvement, the performance rate of enteroscopy was only 30.9%, and thus the majority of the patients have not undergone enteroscopy examinations. Further investigation is required to define the clinical significance of enteroscopy at the initial diagnostic work‑up and during the follow‑up period of these patients.

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