Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

  • Authors:
    • Xiao‑Juan Yu
    • Kun Sun
    • Xiao‑He Tang
    • Cun‑Jin Zhou
    • Hui Sun
    • Zhe Yan
    • Ling Fang
    • Hong‑Wen Wu
    • Yi‑Kui Xie
    • Bin Gu
  • View Affiliations

  • Published online on: June 9, 2016     https://doi.org/10.3892/ol.2016.4696
  • Pages: 983-988
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Abstract

Cyclooxygenase-2 (COX-2) serves an important role in the carcinogenesis and progression of gastric cancer. Harmine (HM) and paclitaxel (PTX) are reported as promising drug candidates for cancer therapy, but whether a synergistic anti-tumor effect of HM combined with PTX exists in human gastric cancer remains unknown. The present study evaluated the effects of HM and/or PTX on cell proliferation and apoptosis in a gastric cancer cell line, SGC-7901. HM and PTX inhibited cell proliferation in a dose‑dependent manner. Both HM and PTX alone induced apoptosis in gastric cancer cells. The combination of HM and PTX exerted synergistic effects on proliferation inhibition and apoptosis induction in SGC‑7901 cells, with down‑regulation of COX-2, PCNA and Bcl‑2 and up‑regulation of Bax expression. The results indicated that combination chemotherapy using HM with PTX exerts an anti‑tumor effect for treating gastric cancer. The combination of the two drugs inhibits gastric cancer development more effectively than each drug alone through down‑regulation of COX‑2 expression.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu XJ, Sun K, Tang XH, Zhou CJ, Sun H, Yan Z, Fang L, Wu HW, Xie YK, Gu B, Gu B, et al: Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncol Lett 12: 983-988, 2016
APA
Yu, X., Sun, K., Tang, X., Zhou, C., Sun, H., Yan, Z. ... Gu, B. (2016). Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncology Letters, 12, 983-988. https://doi.org/10.3892/ol.2016.4696
MLA
Yu, X., Sun, K., Tang, X., Zhou, C., Sun, H., Yan, Z., Fang, L., Wu, H., Xie, Y., Gu, B."Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer". Oncology Letters 12.2 (2016): 983-988.
Chicago
Yu, X., Sun, K., Tang, X., Zhou, C., Sun, H., Yan, Z., Fang, L., Wu, H., Xie, Y., Gu, B."Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer". Oncology Letters 12, no. 2 (2016): 983-988. https://doi.org/10.3892/ol.2016.4696