Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review)

  • Authors:
    • Nadège Kindt
    • Fabrice Journe
    • Guy Laurent
    • Sven Saussez
  • View Affiliations

  • Published online on: August 2, 2016     https://doi.org/10.3892/ol.2016.4929
  • Pages: 2247-2253
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Macrophage migration inhibitory factor (MIF) was originally identified in 1966 by Bloom and Bennett as a pro-inflammatory cytokine involved in the inhibition of macrophage motility. Since then, studies have investigated the functional contribution of this pro‑inflammatory cytokine in several immune diseases, including rheumatoid arthritis and lupus erythematous. Recently, MIF has been reported to be involved in a variety of neoplastic diseases. The present review discusses previous cancer research studies that have investigated the involvement of MIF in carcinogenesis, disease prognosis, tumor cell proliferation and invasion, and tumor‑induced angiogenesis. Finally, potential therapeutic approaches based on the use of MIF antagonists and neutralizing antibodies are examined. The review concludes that MIF could be a good prognostic biomarker in several types of cancer, but also that the inhibition of MIF could represent a novel therapy against cancer.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kindt N, Journe F, Laurent G and Saussez S: Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review). Oncol Lett 12: 2247-2253, 2016
APA
Kindt, N., Journe, F., Laurent, G., & Saussez, S. (2016). Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review). Oncology Letters, 12, 2247-2253. https://doi.org/10.3892/ol.2016.4929
MLA
Kindt, N., Journe, F., Laurent, G., Saussez, S."Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review)". Oncology Letters 12.4 (2016): 2247-2253.
Chicago
Kindt, N., Journe, F., Laurent, G., Saussez, S."Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review)". Oncology Letters 12, no. 4 (2016): 2247-2253. https://doi.org/10.3892/ol.2016.4929