Novel dynamin 2 mutations in adult T‑cell acute lymphoblastic leukemia

Ge,Zheng; Li,Min; Zhao,Gang; Xiao,Lichan; Gu,Yan; Zhou,Xilian; Yu,Michael D.; Li,Jianyong; Dovat,Sinisa; Song,Chunhua

doi:10.3892/ol.2016.4993

Novel dynamin 2 mutations in adult T‑cell acute lymphoblastic leukemia

Authors:
- Zheng Ge
- Min Li
- Gang Zhao
- Lichan Xiao
- Yan Gu
- Xilian Zhou
- Michael D. Yu
- Jianyong Li
- Sinisa Dovat
- Chunhua Song
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Affiliations: Department of Hematology, Key Department of Jiangsu Medicine, Zhongda Hospital, Southeast University Medical School, Nanjing, Jiangsu 210009, P.R. China, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China, Department of Internal Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Published online on: August 10, 2016 https://doi.org/10.3892/ol.2016.4993
Pages: 2746-2751

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Abstract

Genetic mutations on signaling pathways are found in patients with T‑cell acute lymphoblastic leukemia (T‑ALL) and act as markers of high‑risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T‑ALL, particularly in early T‑cell precursor‑ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T‑ALL patients. A total of 4 novel DNM2 mutations were identified in adult T‑ALL patients, with a mutation rate of 9.5%, and the DNM2 mutations were found to co‑exist with NOTCH1 and PHD finger protein 6, and were also associated with high‑risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients' clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T‑ALL.

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