Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

  • Authors:
    • Wen Zheng
    • Shiliu Lu
    • Haolei Cai
    • Muxing Kang
    • Wenjie Qin
    • Chao Li
    • Yulian Wu
  • View Affiliations

  • Published online on: August 2, 2016     https://doi.org/10.3892/ol.2016.4928
  • Pages: 2761-2765
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Abstract

Pancreatic cancer (PC) is a highly lethal malignancy with few effective therapies. Deguelin, a natural compound of the flavonoid family of products, has been reported to have an inhibitory effect on various cancers. In the present study, we investigated whether deguelin had antitumor efficacy in PC. Deguelin treatment was observed to inhibit growth and induce apoptosis in two PC cell lines (Bxpc‑3 and Panc‑1). In addition, it inhibited migration and invasion in these two cell lines. The activation of the hedgehog (Hh) signaling pathway, as well as matrix metalloproteinases (MMP)-2 and MMP-9, was suppressed by deguelin. These results suggest that deguelin may be a potential chemotherapeutic agent for PC, possibly through the suppression of the Hh signaling pathway.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zheng W, Lu S, Cai H, Kang M, Qin W, Li C and Wu Y: Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncol Lett 12: 2761-2765, 2016
APA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., & Wu, Y. (2016). Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncology Letters, 12, 2761-2765. https://doi.org/10.3892/ol.2016.4928
MLA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12.4 (2016): 2761-2765.
Chicago
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12, no. 4 (2016): 2761-2765. https://doi.org/10.3892/ol.2016.4928