Open Access

Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy

  • Authors:
    • Reiko Kobayashi
    • Ryu Miyagawa
    • Hideomi Yamashita
    • Teppei Morikawa
    • Kae Okuma
    • Masashi Fukayama
    • Kuni Ohtomo
    • Keiichi Nakagawa
  • View Affiliations

  • Published online on: August 26, 2016     https://doi.org/10.3892/ol.2016.5054
  • Pages: 3066-3074
  • Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present retrospective study aimed to examine the association between the expression of long non‑protein‑coding RNAs (lncRNAs) and clinical prognosis in the pretreatment formalin-fixed, paraffin-embedded (FFPE) tissue samples of cervical squamous cell carcinoma patients that underwent platinum‑based chemoradiation therapy. Between 2001 and 2013, 49 consecutive patients with squamous cell cervical carcinoma were selected for the present study (median follow‑up period, 44.1 months). The patients possessed an International Federation of Gynecology and Obstetrics stage of IB1/IIA1 (with pelvic lymph node metastasis), IB2 or IIA2‑IVA, and had been treated with definitive chemoradiation therapy. The pretreatment FFPE tumor biopsies of the patients obtained diagnosis were used for analysis. Total RNAs were extracted from the FFPE tumor tissues and reverse transcription‑quantitative polymerase chain reaction was performed to examine the expression level of lncRNAs. The expression level of X inactive‑specific transcript (XIST) demonstrated a significant association with the overall survival rate (P=0.014). The 4‑year overall survival rates were 87.1 and 54.4% in the high and low XIST expression groups, respectively. Since the expression of XIST is associated with the overall survival rate, this lncRNA has the potential to become a predictor for the prognosis of cervical squamous cell carcinoma patients that are treated with chemoradiation therapy. Additional studies are required to investigate the underlying mechanisms of XIST that are associated with prognosis.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kobayashi R, Miyagawa R, Yamashita H, Morikawa T, Okuma K, Fukayama M, Ohtomo K and Nakagawa K: Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy. Oncol Lett 12: 3066-3074, 2016
APA
Kobayashi, R., Miyagawa, R., Yamashita, H., Morikawa, T., Okuma, K., Fukayama, M. ... Nakagawa, K. (2016). Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy. Oncology Letters, 12, 3066-3074. https://doi.org/10.3892/ol.2016.5054
MLA
Kobayashi, R., Miyagawa, R., Yamashita, H., Morikawa, T., Okuma, K., Fukayama, M., Ohtomo, K., Nakagawa, K."Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy". Oncology Letters 12.5 (2016): 3066-3074.
Chicago
Kobayashi, R., Miyagawa, R., Yamashita, H., Morikawa, T., Okuma, K., Fukayama, M., Ohtomo, K., Nakagawa, K."Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy". Oncology Letters 12, no. 5 (2016): 3066-3074. https://doi.org/10.3892/ol.2016.5054