Open Access

Receptor tyrosine kinases in carcinogenesis (Review)

Retraction in: /10.3892/ol.2020.12062

  • Authors:
    • Xiao-Ying Zhang
    • Pei-Ying Zhang
  • View Affiliations

  • Published online on: September 28, 2016     https://doi.org/10.3892/ol.2016.5200
  • Pages: 3679-3682
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Receptor tyrosine kinases (RTKs) are cell surface glycoproteins with enzymatic activity involved in the regulation of various important functions. In all-important physiological functions including differentiation, cell-cell interactions, survival, proliferation, metabolism, migration and signaling these receptors are the key players of regulation. Additionally, mutations of RTKs or their overexpression have been described in many human cancers and are being explored as a novel avenue for a new therapeutic approach. Some of the deregulated RTKs observed to be significantly affected in cancers included vascular endothelial growth factor receptor, epidermal growth factor receptor, fibroblast growth factor receptor, RTK-like orphan receptor 1 (ROR1) and the platelet‑derived growth factor receptor. These deregulated RTKs offer attractive possibilities for the new anticancer therapeutic approach involving specific targeting by monoclonal antibodies as well as kinase. The present review aimed to highlight recent perspectives of RTK ROR1 in cancer.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X and Zhang X: Receptor tyrosine kinases in carcinogenesis (Review) Retraction in /10.3892/ol.2020.12062. Oncol Lett 12: 3679-3682, 2016
APA
Zhang, X., & Zhang, X. (2016). Receptor tyrosine kinases in carcinogenesis (Review) Retraction in /10.3892/ol.2020.12062. Oncology Letters, 12, 3679-3682. https://doi.org/10.3892/ol.2016.5200
MLA
Zhang, X., Zhang, P."Receptor tyrosine kinases in carcinogenesis (Review) Retraction in /10.3892/ol.2020.12062". Oncology Letters 12.5 (2016): 3679-3682.
Chicago
Zhang, X., Zhang, P."Receptor tyrosine kinases in carcinogenesis (Review) Retraction in /10.3892/ol.2020.12062". Oncology Letters 12, no. 5 (2016): 3679-3682. https://doi.org/10.3892/ol.2016.5200