Primary mesenchymal tumors of the pancreas in a single center over 15 years

Zhang,Hongkai; Yu,Shuangni; Wang,Wenze; Cheng,Yin; Xiao,Yu; Lu,Zhaohui; Chen,Jie

doi:10.3892/ol.2016.5155

Primary mesenchymal tumors of the pancreas in a single center over 15 years

Authors:
- Hongkai Zhang
- Shuangni Yu
- Wenze Wang
- Yin Cheng
- Yu Xiao
- Zhaohui Lu
- Jie Chen
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Affiliations: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
Published online on: September 20, 2016 https://doi.org/10.3892/ol.2016.5155
Pages: 4027-4034

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Abstract

In total, 95% of primary tumors in the pancreas are epithelial tumors; primary mesenchymal tumors at this site are extremely rare. At present, only one comprehensive study about these rare tumors has been performed. Another retrospective analysis of these rare tumors is performed in the present study, which, to the best of our knowledge, is the first to be performed in China. In the present study, 10 patients that underwent resection for primary mesenchymal tumors of the pancreas were identified in a 15‑year period at the Chinese Academy of Medical Sciences and Peking Union Medical College, which accounted for 0.51% of the total surgically resected primary tumors of the pancreas at this hospital. Among the 10 patients, 7 patients (70%) were diagnosed with benign/borderline tumors, and the remaining 3 patients (30%) were diagnosed with malignant tumors. It was a unique finding of the present study that the preoperative diagnosis was frequently a misdiagnosis, in terms of the specific pathological diagnosis. Therefore, although primary mesenchymal tumors of the pancreas are extremely rare, they should be considered in order to make the correct preoperative diagnosis. Contrarily to a previous study, in the present study, the most common benign tumor was not desmoid tumor, but solitary fibrous tumors; the most frequent primary sarcoma was not undifferentiated/unclassified sarcoma either. In conclusion, the present study aids the understanding of these rare tumors; however, primary mesenchymal tumors of the pancreas require additional exploration in the future.

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