N‑terminal truncated carboxypeptidase E expression is associated with poor prognosis of lung adenocarcinoma

Sun,Jing; Meng,Dawei; Li,Li; Tian,Xin; Jia,Yunji; Wang,Hongyue; Yu,Huihui; Sun,Tiemin; Qu,Aibing; Shen,Hui; Bao,Jimin; Zhang,Guirong

doi:10.3892/ol.2016.5283

N‑terminal truncated carboxypeptidase E expression is associated with poor prognosis of lung adenocarcinoma

Authors:
- Jing Sun
- Dawei Meng
- Li Li
- Xin Tian
- Yunji Jia
- Hongyue Wang
- Huihui Yu
- Tiemin Sun
- Aibing Qu
- Hui Shen
- Jimin Bao
- Guirong Zhang
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Affiliations: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China, Department of Otolaryngology‑Head and Neck Surgery, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, P.R. China, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China, Molecular Oncology Laboratory, Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of General Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Department of Epidemiology, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China
Published online on: October 18, 2016 https://doi.org/10.3892/ol.2016.5283
Pages: 4659-4664

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Abstract

Lung cancer is a malignant tumor with high morbidity and mortality rates. To date, no suitable molecular diagnostic tool to predict disease recurrence and metastasis has been identified. The current study aimed to evaluate the potential of N‑terminal truncated carboxypeptidase E (CPEΔN) to predict the recurrence and metastasis of lung adenocarcinoma. Western blotting revealed the co‑expression of CPE and CPEΔN in the surgically collected pathological and pericarcinoma tissues tissues of 62.1% (59/95) lung adenocarcinoma patients. The full length CPE protein was predominantly expressed in pericarcinoma tissues and CPEΔN expression was identified in the pericarcinoma normal tissues of only 5.26% (5/95) patients. The 3‑year postoperative recurrence and metastasis rates were significantly higher in patients with positive CPEΔN expression than in patients with negative CPEΔN expression (P=0.009). Furthermore, the overall survival rate of patients with predominant nuclear CPE expression was lower than that of patients with predominant cytoplasmic CPE expression (46.3 vs. 64.7%); however, no statistically significant difference was identified (P=0.125). Thus, the results of the current study indicated that CPEΔN may present a novel molecular biomarker for predicting recurrence and metastasis of lung adenocarcinoma, which may aid with stratifying patients by risk and thus, may facilitate individualized therapy.

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