Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice

  • Authors:
    • Daniel Boff Lima
    • Raphael Carmo Valente
    • Marcia Alves Marques Capella
  • View Affiliations

  • Published online on: November 8, 2016     https://doi.org/10.3892/ol.2016.5366
  • Pages: 5275-5280
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ouabain is a glycoside with immunomodulating properties, and recent studies have suggested its use in adjuvant therapy for cancer treatment. Ouabain is known to modulate the immune system in vitro, and previous studies have revealed that ouabain can modulate the expression and activity of ABCB1, a protein associated with multidrug resistance present in immune system. Therefore, the present study investigated alterations in the expression and activity of ABCB1 in the thymi, peripheral blood monocytes and lymph nodes of Wistar rats and Swiss mice treated acutely or chronically with ouabain. A decrease of almost 45% in the monocyte count and an increase of 55% in the basophil count were observed. A significant decrease (75% reduction) in the amount of cells with ABCB1 activity was found in the thymocytes of ouabain‑treated rats and mice. The possible implications of these results for cancer treatment are discussed.
View Figures
View References

Related Articles

Journal Cover

December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lima DB, Valente RC and Capella MA: Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice. Oncol Lett 12: 5275-5280, 2016
APA
Lima, D.B., Valente, R.C., & Capella, M.A. (2016). Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice. Oncology Letters, 12, 5275-5280. https://doi.org/10.3892/ol.2016.5366
MLA
Lima, D. B., Valente, R. C., Capella, M. A."Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice". Oncology Letters 12.6 (2016): 5275-5280.
Chicago
Lima, D. B., Valente, R. C., Capella, M. A."Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice". Oncology Letters 12, no. 6 (2016): 5275-5280. https://doi.org/10.3892/ol.2016.5366