Prognostic significance of the preoperative lymphocyte‑to‑monocyte ratio in patients with colorectal cancer

  • Authors:
    • Masatsune Shibutani
    • Kiyoshi Maeda
    • Hisashi Nagahara
    • Yasuhito Iseki
    • Tetsuro Ikeya
    • Kosei Hirakawa
  • View Affiliations

  • Published online on: December 12, 2016     https://doi.org/10.3892/ol.2016.5487
  • Pages: 1000-1006
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Abstract

A correlation between the lymphocyte‑to‑monocyte ratio (LMR) and the survival of patients with hematological malignancies has been reported previously. However, there have been few studies investigating the prognostic significance of LMR in patients with solid tumors. The aim of the present study was to evaluate the prognostic significance of preoperative LMR in patients with colorectal cancer (CRC). A total of 189 patients undergoing potentially curative surgery for CRC were enrolled. The LMR was calculated from preoperative blood samples by dividing absolute lymphocyte count by absolute monocyte count. A cut‑off value of 4.8 was set based on the receiver operating characteristic curve; 116 patients were classified as high‑LMR, and 73 patients classified as low‑LMR. The high‑LMR group exhibited significantly better relapse‑free survival (P=0.0018) and overall survival (P=0.0127) rates than the low‑LMR group. According to the multivariate analysis of survival, preoperative LMR was identified as an independent prognostic factor for relapse‑free survival (P=0.041) and overall survival (P=0.031). Therefore, preoperative LMR is a useful prognostic marker in patients with CRC.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shibutani M, Maeda K, Nagahara H, Iseki Y, Ikeya T and Hirakawa K: Prognostic significance of the preoperative lymphocyte‑to‑monocyte ratio in patients with colorectal cancer. Oncol Lett 13: 1000-1006, 2017.
APA
Shibutani, M., Maeda, K., Nagahara, H., Iseki, Y., Ikeya, T., & Hirakawa, K. (2017). Prognostic significance of the preoperative lymphocyte‑to‑monocyte ratio in patients with colorectal cancer. Oncology Letters, 13, 1000-1006. https://doi.org/10.3892/ol.2016.5487
MLA
Shibutani, M., Maeda, K., Nagahara, H., Iseki, Y., Ikeya, T., Hirakawa, K."Prognostic significance of the preoperative lymphocyte‑to‑monocyte ratio in patients with colorectal cancer". Oncology Letters 13.2 (2017): 1000-1006.
Chicago
Shibutani, M., Maeda, K., Nagahara, H., Iseki, Y., Ikeya, T., Hirakawa, K."Prognostic significance of the preoperative lymphocyte‑to‑monocyte ratio in patients with colorectal cancer". Oncology Letters 13, no. 2 (2017): 1000-1006. https://doi.org/10.3892/ol.2016.5487