Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line

  • Authors:
    • Ping Mao
    • Ershao Zhang
    • Yang Chen
    • Likun Liu
    • Daqing Rong
    • Qingfeng Liu
    • Weiling Li
  • View Affiliations

  • Published online on: December 16, 2016     https://doi.org/10.3892/ol.2016.5509
  • Pages: 1019-1023
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Abstract

The bark of Pinus massoniana is a traditional Chinese medicine for the treatment of various health disorders. Previous studies have demonstrated that P. massoniana bark extract (PMBE) may induce the apoptosis of hepatoma and cervical cancer cells. However, whether PMBE is able to inhibit the migration of lung cancer cells requires further investigation. In the current study, the effects of PMBE on the viability of human lung cancer A549 cells were detected using an MTT assay. The migration of lung cancer cells following exposure to PMBE were quantified using wound healing and Transwell assays, respectively. The expression levels of matrix metalloproteinase (MMP)‑9 were determined using western blotting. The results revealed that PMBE significantly inhibited the growth of the lung cancer cells. In addition, the wound closure rate and the migration of the lung cancer cells were suppressed by PMBE. Furthermore, the expression levels of MMP‑9 were reduced. These findings indicated that PMBE is able to restrict the migration and invasion of lung cancer cells, and that PMBE may serve as a novel therapeutic agent for patients with metastatic lung cancer in the future.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Mao P, Zhang E, Chen Y, Liu L, Rong D, Liu Q and Li W: Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line. Oncol Lett 13: 1019-1023, 2017
APA
Mao, P., Zhang, E., Chen, Y., Liu, L., Rong, D., Liu, Q., & Li, W. (2017). Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line. Oncology Letters, 13, 1019-1023. https://doi.org/10.3892/ol.2016.5509
MLA
Mao, P., Zhang, E., Chen, Y., Liu, L., Rong, D., Liu, Q., Li, W."Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line". Oncology Letters 13.2 (2017): 1019-1023.
Chicago
Mao, P., Zhang, E., Chen, Y., Liu, L., Rong, D., Liu, Q., Li, W."Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line". Oncology Letters 13, no. 2 (2017): 1019-1023. https://doi.org/10.3892/ol.2016.5509