Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients

  • Authors:
    • Shijie Qiu
    • Zhaoxia Xia
    • Qun Li
    • Dong Ye
    • Qi Huang
    • Zhisen Shen
  • View Affiliations

  • Published online on: December 27, 2016     https://doi.org/10.3892/ol.2016.5541
  • Pages: 1311-1314
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Abstract

The aim of the present study was to investigate the expression levels of Yes-associated protein (YAP) in different grades of laryngeal squamous cell carcinoma (LSCC) tissues and vocal cord polyps tissues, and to investigate any correlations with clinical factors. The expression of YAP in 128 cases of LSCC and 10 cases of vocal cord polyps tissues was tested using immunohistochemistry. YAP was primarily present in the nucleus of LSCC and controls, whereas phosphorylated YAP expression was present in the cytoplasm. The results indicated that YAP expression was upregulated in LSCC samples compared with vocal cord polyps tissues. YAP expression was positively correlated with the malignant degree of LSCC (P<0.01) and a high level of YAP expression in LSCC tissues was correlated with pathological type, lymphatic metastasis and clinical stage. The present study provided evidence for the expression and localization of YAP in LSCC and vocal cord polyps tissues. Thus, YAP may be involved in the occurrence and development of LSCC as an oncogene.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
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Spandidos Publications style
Qiu S, Xia Z, Li Q, Ye D, Huang Q and Shen Z: Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncol Lett 13: 1311-1314, 2017
APA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., & Shen, Z. (2017). Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncology Letters, 13, 1311-1314. https://doi.org/10.3892/ol.2016.5541
MLA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13.3 (2017): 1311-1314.
Chicago
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13, no. 3 (2017): 1311-1314. https://doi.org/10.3892/ol.2016.5541