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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)

  • Authors:
    • Carlos Martínez‑Campa
    • Javier Menéndez‑Menéndez
    • Carolina Alonso‑González
    • Alicia González
    • Virginia Álvarez‑García
    • Samuel Cos

  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Research Institute Valdecilla, 39011 Santander, Spain, Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, EH14 4AS Edinburgh, UK
    Copyright: © Martínez‑Campa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2003-2014
    |
    Published online on: February 10, 2017
       https://doi.org/10.3892/ol.2017.5712
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Abstract

Melatonin, synthesized in and released from the pineal gland, has been demonstrated by multiple in vivo and in vitro studies to have an oncostatic role in hormone‑dependent tumors. Furthermore, several clinical trials point to melatonin as a promising adjuvant molecule to be considered for cancer treatment. In the past few years, evidence of a broader spectrum of action of melatonin as an antitumor agent has arisen; thus, melatonin appears to also have therapeutic effects in several types of hormone‑independent cancer, including ovarian, leukemic, pancreatic, gastric and non‑small cell lung carcinoma. In the present study, the latest findings regarding melatonin molecular actions when concomitantly administered with either radiotherapy or chemotherapy in cancer were reviewed, with a particular focus on hormone-dependent breast cancer. Finally, the present study discusses which direction should be followed in the next years to definitely clarify whether or not melatonin administration could protect against non-desirable effects (such as altered gene expression and post-translational protein modifications) caused by chemotherapy or radiotherapy treatments. As treatments move towards personalized medicine, comparative gene expression profiling with and without melatonin may be a powerful tool to better understand the antitumor effects of melatonin, the pineal gland hormone.

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Copy and paste a formatted citation
Spandidos Publications style
Martínez‑Campa C, Menéndez‑Menéndez J, Alonso‑González C, González A, Álvarez‑García V and Cos S: What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review). Oncol Lett 13: 2003-2014, 2017.
APA
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., & Cos, S. (2017). What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review). Oncology Letters, 13, 2003-2014. https://doi.org/10.3892/ol.2017.5712
MLA
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., Cos, S."What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)". Oncology Letters 13.4 (2017): 2003-2014.
Chicago
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., Cos, S."What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)". Oncology Letters 13, no. 4 (2017): 2003-2014. https://doi.org/10.3892/ol.2017.5712
Copy and paste a formatted citation
x
Spandidos Publications style
Martínez‑Campa C, Menéndez‑Menéndez J, Alonso‑González C, González A, Álvarez‑García V and Cos S: What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review). Oncol Lett 13: 2003-2014, 2017.
APA
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., & Cos, S. (2017). What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review). Oncology Letters, 13, 2003-2014. https://doi.org/10.3892/ol.2017.5712
MLA
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., Cos, S."What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)". Oncology Letters 13.4 (2017): 2003-2014.
Chicago
Martínez‑Campa, C., Menéndez‑Menéndez, J., Alonso‑González, C., González, A., Álvarez‑García, V., Cos, S."What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)". Oncology Letters 13, no. 4 (2017): 2003-2014. https://doi.org/10.3892/ol.2017.5712
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