Open Access

Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype

  • Authors:
    • Hye‑Rin Park
    • Eun‑Ji Lee
    • Seong‑Cheol Moon
    • Tae‑Wook Chung
    • Keuk‑Jun Kim
    • Hwa‑Seung Yoo
    • Chong‑Kwan Cho
    • Ki‑Tae Ha
  • View Affiliations

  • Published online on: February 13, 2017     https://doi.org/10.3892/ol.2017.5730
  • Pages: 2330-2336
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Re-education of tumor-associated macrophages (TAMs) toward antitumor effectors may be a promising therapeutic strategy for the successful treatment of cancer. HangAmDan‑B (HAD‑B), a herbal formula, has been used for stimulating immune function and activation of vital energy to cancer patients in traditional Korean Medicine. Previous studies have reported the anti-angiogenic and anti‑metastatic effects of HAD‑B; however, evidence on the immunomodulatory action of HAD‑B was not demonstrated. In the present study, immunocompetent mice were used to demonstrate the suppression of the in vivo growth of allograft Lewis lung carcinoma (LLC) cells, by HAD‑B. In addition, HAD‑B inhibited the in vitro growth of LLC cells by driving macrophages toward M1 polarization, but not through direct inhibition of tumor cell growth. Furthermore, culture media transfer of HAD‑B‑treated macrophages induced apoptosis of LLC cells. Results of the present study suggest that the antitumor effect of HAD‑B may be explained by stimulating the antitumor function of macrophages. Considering the importance of re‑educating TAMs in the regulation of the tumor microenvironment, the present study may confer another option for anti-cancer therapeutic strategy, using herbal medicines such as HAD-B.

Related Articles

Journal Cover

April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Park HR, Lee EJ, Moon SC, Chung TW, Kim KJ, Yoo HS, Cho CK and Ha KT: Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype. Oncol Lett 13: 2330-2336, 2017
APA
Park, H., Lee, E., Moon, S., Chung, T., Kim, K., Yoo, H. ... Ha, K. (2017). Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype. Oncology Letters, 13, 2330-2336. https://doi.org/10.3892/ol.2017.5730
MLA
Park, H., Lee, E., Moon, S., Chung, T., Kim, K., Yoo, H., Cho, C., Ha, K."Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype". Oncology Letters 13.4 (2017): 2330-2336.
Chicago
Park, H., Lee, E., Moon, S., Chung, T., Kim, K., Yoo, H., Cho, C., Ha, K."Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype". Oncology Letters 13, no. 4 (2017): 2330-2336. https://doi.org/10.3892/ol.2017.5730