Expression of autophagy‑associated proteins in papillary thyroid carcinoma

Yang,Meiliu; Bai,Lu; Yu,Wu; Sun,Xueling; Xu,Gang; Guan,Ruhua; Yang,Ying; Qiu,Mingyue; Zhang,Yazhong; Tian,Jinli; Fang,Hui

doi:10.3892/ol.2017.6101

Expression of autophagy‑associated proteins in papillary thyroid carcinoma

Authors:
- Meiliu Yang
- Lu Bai
- Wu Yu
- Xueling Sun
- Gang Xu
- Ruhua Guan
- Ying Yang
- Mingyue Qiu
- Yazhong Zhang
- Jinli Tian
- Hui Fang
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Affiliations: Department of Medical Experimental Center, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Surgery, Qianan Yejituo Hospital, Qianan, Hebei 064400, P.R. China, Department of Endocrinology, Tangshan Worker Hospital, Tangshan, Hebei 063000, P.R. China, Department of Burn, Tangshan Worker Hospital, Tangshan, Hebei 063000, P.R. China, Department of Endocrinology, Hebei Yanda Hospital, San He, Hebei 065201, P.R. China
Published online on: April 28, 2017 https://doi.org/10.3892/ol.2017.6101
Pages: 411-415

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Abstract

The present study was designed to assess the protein expression of the autophagy‑associated genes, Beclin‑1 and microtubule‑associated protein 1 light chain 3 (LC3)‑II, as well as the association with clinicopathological features in papillary thyroid carcinoma (PTC). A total of 50 subjects were recruited, including 50 human PTC samples and paired adjacent noncancerous tissue samples. The protein expression of Beclin‑1 and LC3‑II was analyzed using immunohistochemistry and western blotting. Beclin‑1 and LC3‑II expression in PTC tissues significantly reduced compared with normal tissues (P<0.05). Expression of Beclin‑1 and LC3‑II was associated with lymph node metastasis of PTC (P<0.05), but had no association with age, gender, tumor size, tumor number and Tumor‑Node‑Metastasis stage (P>0.05). Expression of Beclin‑1 and LC3‑II were positively correlated (r=0.327;P=0.020) in PTC. In conclusion, the activity of autophagy was declined in PTC; this decrease in autophagic capacity may be associated with tumorigenesis and the development of PTC.

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