Open Access

Yes‑associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma (Review)

  • Authors:
    • Liang Shan
    • Hongyuan Jiang
    • Lifang Ma
    • Yongchun Yu
  • View Affiliations

  • Published online on: July 20, 2017     https://doi.org/10.3892/ol.2017.6622
  • Pages: 3291-3296
  • Copyright: © Shan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is a common type of malignant tumor. The early‑diagnosis and treatment options for HCC are limited, which is primarily due to an incomplete understanding of the underlying molecular mechanisms of the disease. Yes‑associated protein (YAP) overexpression promotes proliferation and phenotypic transformation of HCC cells. Recently, elucidating the molecular mechanisms of the Hippo/YAP signaling pathway and investigating the interactions between the signaling molecules, as a potential strategy for the treatment of HCC, has become an area of interest. The present review will discuss the role of YAP in HCC pathogenesis, and the significance of YAP in diagnosis, treatment and determining the prognosis.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shan L, Jiang H, Ma L and Yu Y: Yes‑associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma (Review). Oncol Lett 14: 3291-3296, 2017
APA
Shan, L., Jiang, H., Ma, L., & Yu, Y. (2017). Yes‑associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma (Review). Oncology Letters, 14, 3291-3296. https://doi.org/10.3892/ol.2017.6622
MLA
Shan, L., Jiang, H., Ma, L., Yu, Y."Yes‑associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma (Review)". Oncology Letters 14.3 (2017): 3291-3296.
Chicago
Shan, L., Jiang, H., Ma, L., Yu, Y."Yes‑associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma (Review)". Oncology Letters 14, no. 3 (2017): 3291-3296. https://doi.org/10.3892/ol.2017.6622