MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review)

  • Authors:
    • Xuemei Fan
    • Wei Chen
    • Ziyi Fu
    • Lihua Zeng
    • Yongmei Yin
    • Hongyan Yuan
  • View Affiliations

  • Published online on: September 1, 2017     https://doi.org/10.3892/ol.2017.6867
  • Pages: 5069-5076
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Abstract

Cancer stem cells (CSCs; also known as tumor‑initia­ting cells) are essential effectors of tumor progression due to their self‑renewal capacity, differentiation potential, tumorigenic ability and resistance to chemotherapy, all of which contribute to cancer relapse, metastasis and a poor prognosis. Breast cancer stem cells (BCSCs) have been identified to be involved in the processes of BC initiation, growth and recurrence. MicroRNAs (miRNAs) are a class of non‑coding small RNAs of 19‑23 nucleotides in length that regulate gene expression at the post‑transcriptional level through various mechanisms, and serve critical roles in cancer progression. miRNAs have been demonstrated to elicit effects on BCSCs characteristics via the targeting of oncogenes or tumor suppressor genes. The present study focused on the effect of miRNAs on BCSC, including BCSC formation, self‑renewal and differentiation, by which miRNAs may inhibit BCSC invasion and metastasis, modulate clonogenicity and tumorigenicity of BCSCs as well as regulate chemotherapy resistance to BC. Through an improved understanding of the association between BCSCs and miRNAs, a novel and safer therapeutic target for BC may be identified.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fan X, Chen W, Fu Z, Zeng L, Yin Y and Yuan H: MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review). Oncol Lett 14: 5069-5076, 2017
APA
Fan, X., Chen, W., Fu, Z., Zeng, L., Yin, Y., & Yuan, H. (2017). MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review). Oncology Letters, 14, 5069-5076. https://doi.org/10.3892/ol.2017.6867
MLA
Fan, X., Chen, W., Fu, Z., Zeng, L., Yin, Y., Yuan, H."MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review)". Oncology Letters 14.5 (2017): 5069-5076.
Chicago
Fan, X., Chen, W., Fu, Z., Zeng, L., Yin, Y., Yuan, H."MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review)". Oncology Letters 14, no. 5 (2017): 5069-5076. https://doi.org/10.3892/ol.2017.6867