Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer

  • Authors:
    • Xiying Shao
    • Lei Luo
    • Yong Guo
    • Xiaohong Xu
    • Dehou Deng
    • Jianguo Feng
    • Yuheng Ding
    • Hanzhou Mou
    • Ping Huang
    • Lei Shi
    • Yuan Huang
    • Weiwu Ye
    • Caijin Lou
    • Zhanhong Chen
    • Yabing Zheng
    • Xiaojia Wang
  • View Affiliations

  • Published online on: September 18, 2017     https://doi.org/10.3892/ol.2017.6984
  • Pages: 6156-6162
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Abstract

It has been hypothesized that single nucleotide polymorphisms in CYP19A1 gene may alter aromatase activity and circulating steroid hormone levels in females. Therefore, it is biologically reasonable that CYP19A1 rs1008805 (A/G) polymorphism may be associated with the clinical outcome of hormone therapy. Genotyping for the CYP19A1 rs1008805 polymorphism was performed for 287 females with hormone receptor (HR)‑positive early breast cancer, and potential associations were evaluated between CYP19A1 rs1008805 genotypes and disease‑free survival (DFS). Based on the analysis of the whole cohort, no significant differences were observed between rs1008805 genotypes and DFS. However, in postmenopausal females, rs1008805 variants were significantly associated with DFS (AA vs. AG vs. GG, 89.2 vs. 58.2 vs. 32.7 months; P=0.019). In addition, when the population was divided into two cohorts, females with the GG variant exhibited a significantly poorer DFS [GG vs. AA or AG, 32.7 vs. 70.6 months; hazard ratio (HR), 3.613; 95% confidence interval (CI), 1.380‑9.457; P=0.005]. Furthermore, when adjusted for other patient features in multivariate analyses, GG genotype remained an independent prognostic marker for DFS (HR, 3.439; 95% CI, 1.251‑9.456; P=0.017). However, there were no significant differences in DFS between patients harboring the minor allele and those with the homozygous common allele (AG or GG vs. AA, 52.4 vs. 89.2 months; HR, 1.288; 95% CI, 0.705‑2.353; P=0.408). There were also no associations between rs1008805 polymorphism and DFS for premenopausal females. In conclusion, the homozygous minor allele (GG) of CYP19A1 rs1008805 was identified to be significantly associated with an inferior clinical outcome of hormone therapy in postmenopausal hormone receptor‑positive patients with early breast cancer. If confirmed by further study, genotyping for CYP19A1 rs1008805 polymorphism may provide predictive information to improve the selection of endocrine treatment.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shao X, Luo L, Guo Y, Xu X, Deng D, Feng J, Ding Y, Mou H, Huang P, Shi L, Shi L, et al: Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer. Oncol Lett 14: 6156-6162, 2017
APA
Shao, X., Luo, L., Guo, Y., Xu, X., Deng, D., Feng, J. ... Wang, X. (2017). Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer. Oncology Letters, 14, 6156-6162. https://doi.org/10.3892/ol.2017.6984
MLA
Shao, X., Luo, L., Guo, Y., Xu, X., Deng, D., Feng, J., Ding, Y., Mou, H., Huang, P., Shi, L., Huang, Y., Ye, W., Lou, C., Chen, Z., Zheng, Y., Wang, X."Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer". Oncology Letters 14.5 (2017): 6156-6162.
Chicago
Shao, X., Luo, L., Guo, Y., Xu, X., Deng, D., Feng, J., Ding, Y., Mou, H., Huang, P., Shi, L., Huang, Y., Ye, W., Lou, C., Chen, Z., Zheng, Y., Wang, X."Rs1008805 polymorphism of CYP19A1 gene is associated with the efficacy of hormone therapy in stage I‑II and operable stage III breast cancer". Oncology Letters 14, no. 5 (2017): 6156-6162. https://doi.org/10.3892/ol.2017.6984