Open Access

Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70

  • Authors:
    • Wenshuai Li
    • Huilu Zhang
    • Pei Min
    • Jie Zhu
    • Diannan Xu
    • Weiru Jiang
    • Yanyun Ma
    • Jigang Qiu
    • Weihong Xu
    • Jian Chen
    • Mingqing Zhang
    • Min Li
    • Dongqin Yang
    • Jianping Shi
    • Jun Zhang
    • Jie Liu
  • View Affiliations

  • Published online on: September 28, 2017     https://doi.org/10.3892/ol.2017.7091
  • Pages:6345-6354
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR‑1269a rs73239138 has a role in decreasing the risk of gastric cancer. The level of miR‑1269a variant expression was significantly downregulated compared with the wild‑type miR‑1269a in the gastric cells (Fig. 1). Furthermore, overexpression of miR‑1269a inhibited apoptosis of gastric cancer cells. Expression of the miR‑1269a variant inhibited the function of miR‑1269a by increasing the apoptotic rate and the expression of Bik, Bim and Bak was upregulated consistently. In addition, zinc‑finger protein 70 (ZNF70) was identified to be a target gene of miR‑1269a, which was downregulated by miR‑1269a and upregulated by miR‑1269a variant. ZNF70 was indicated to exert a role as a tumor suppressor in gastric cancer. To the best our knowledge, the present study for the first time highlights a critical role of miR‑1269a variant rs73239138 in decreasing the susceptibility to gastric cancer by downregulating its expression and targeting ZNF70, which promotes apoptosis of gastric cancer cells. This SNP is indicated to serve as a potential biomarker and therapeutic target for gastric cancer.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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Copy and paste a formatted citation
APA
Li, W., Zhang, H., Min, P., Zhu, J., Xu, D., Jiang, W. ... Liu, J. (2017). Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70. Oncology Letters, 14, 6345-6354. https://doi.org/10.3892/ol.2017.7091
MLA
Li, W., Zhang, H., Min, P., Zhu, J., Xu, D., Jiang, W., Ma, Y., Qiu, J., Xu, W., Chen, J., Zhang, M., Li, M., Yang, D., Shi, J., Zhang, J., Liu, J."Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70". Oncology Letters 14.6 (2017): 6345-6354.
Chicago
Li, W., Zhang, H., Min, P., Zhu, J., Xu, D., Jiang, W., Ma, Y., Qiu, J., Xu, W., Chen, J., Zhang, M., Li, M., Yang, D., Shi, J., Zhang, J., Liu, J."Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70". Oncology Letters 14, no. 6 (2017): 6345-6354. https://doi.org/10.3892/ol.2017.7091