Diagnosis and treatment of a carotid body tumor: A case report of a rare bilateral tumor

Sun,Qiang; Xie,Chenlu; Niu,Zhixing; Su,Lei; Wang,Xi; Fang,Zheng; Zhao,Junfang; Chen,Shuai; Li,Xinming; Sun,Minglei

doi:10.3892/ol.2017.7101

Diagnosis and treatment of a carotid body tumor: A case report of a rare bilateral tumor

Authors:
- Qiang Sun
- Chenlu Xie
- Zhixing Niu
- Lei Su
- Xi Wang
- Zheng Fang
- Junfang Zhao
- Shuai Chen
- Xinming Li
- Minglei Sun
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Affiliations: Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: September 28, 2017 https://doi.org/10.3892/ol.2017.7101
Pages: 6417-6420
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present case report, a rare bilateral carotid body tumor (CBT) and the imaging and pathological features of a CBT are described. In the present report, a rare case of bilateral carotid body tumor, which developed in the bifurcation of the common carotid artery, and the clinical manifestations, imaging and pathological features of this CBT are summarized. The imaging cannot validate the diagnosis; however, imaging identified that the tumor exhibited an intact envelope. Immunohistochemical staining revealed that the tumor cells were strongly positive for cluster of differentiation 56, Syn and protein S‑100, moderately positive for transcription factor E3, negative for cytokeratin and epithelial membrane antigen, and partial cells were weakly positive for Desmir (<5%). In view of the clinical and pathological features of the carotid body tumor, surgery is hypothesized to be the optimal treatment and may enable the tumor to be resected completely. Refined surgical techniques provide the security of safe resection and decrease the risk of complications occurring.

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1	Casarim AL, Tincani AJ, Del Negro A, Aguiar CG, Fanni RV and Martins AS: Carotid body tumor: Retrospective analysis on 22 patients. Sao Paulo Med J. 132:133–139. 2014. View Article : Google Scholar : PubMed/NCBI
2	Nora JD, Hallett JW Jr, O'Brien PC, Naessens JM, Cherry KJ Jr and Pairolero PC: Surgical resection of carotid body tumors: Long-term survival, recurrence, and metastasis. Mayo Clin Proc. 63:348–352. 1988. View Article : Google Scholar : PubMed/NCBI
3	Wieneke JA and Smith A: Paraganglioma: Carotid body tumor. Head Neck Pathol. 3:303–306. 2009. View Article : Google Scholar : PubMed/NCBI
4	Sanghvi VD and Chandawarkar RY: Carotid body tumors. J Surg Oncol. 54:190–192. 1993. View Article : Google Scholar : PubMed/NCBI
5	Brown JS: Glomus jugulare tumors revisited: A ten-year statistical follow-up of 231 cases. Laryngoscope. 95:284–288. 1985. View Article : Google Scholar : PubMed/NCBI
6	Offergeld C, Brase C, Yaremchuk S, Mader I, Rischke HC, Gläsker S, Schmid KW, Wiech T, Preuss SF, Suárez C, et al: Head and neck paragangliomas: Clinical and molecular genetic classification. Clinics (Sao Paulo). 67 Suppl 1:S19–S28. 2012. View Article : Google Scholar
7	Kapoor R, Saha MM, Das DK, Gupta AK and Tyagi S: Carotid body tumor initially diagnosed by fine needle aspiration cytology. Acta Cytol. 33:682–683. 1989.PubMed/NCBI
8	Lim JY, Kim J, Kim SH, Lee S, Lim YC, Kim JW and Choi EC: Surgical treatment of carotid body paragangliomas: Outcomes and complications according to the shamblin classification. Clin Exp Otorhinolaryngol. 3:91–95. 2010. View Article : Google Scholar : PubMed/NCBI
9	Williams MD, Phillips MJ, Nelson WR and Rainer WG: Carotid body tumor. Arch Surg. 127:963–968. 1992. View Article : Google Scholar : PubMed/NCBI
10	Zhao FY, Gao Y, Wu MJ, Luo QF, Liu Y and Xu ZQ: Diagnosis and therapy on hemangiomas and vascular malformation in view of the new classification. Beijing Da Xue Xue Bao. 41:21–27. 2009.(In Chinese). PubMed/NCBI
11	Muhm M, Polterauer P, Gstöttner W, Temmel A, Losert H, Richling B, Undt G, Niederle B, Staudacher M, Kretschmer G and Ehringer H: Glomus caroticum chemodectoma. Review on current diagnosis and therapy. Wien Klin Wochenschr. 112:115–120. 2000.(In German). PubMed/NCBI
12	Demattè S, Di Sarra D, Schiavi F, Casadei A and Opocher G: Role of ultrasound and color Doppler imaging in the detection of carotid paragangliomas. J Ultrasound. 15:158–163. 2012. View Article : Google Scholar : PubMed/NCBI
13	Arya S, Rao V, Juvekar S and Dcruz AK: Carotid body tumors: Objective criteria to predict the Shamblin group on MR imaging. AJNR Am J Neuroradiol. 29:1349–1354. 2008. View Article : Google Scholar : PubMed/NCBI
14	Ruby R, Gullane PJ and Mintz D: Chemodectomas of the head and neck. J Otolaryngol. 10:126–136. 1981.PubMed/NCBI
15	Liapis C, Gougoulakis A, Karydakis V, Verikokos C, Doussaitou B, Skandalakis P, Gogas J and Sechas M: Changing trends in management of carotid body tumors. Am Surg. 61:989–993. 1995.PubMed/NCBI
16	Pellitteri PK, Rinaldo A, Myssiorek D, Jackson Gary C, Bradley PJ, Devaney KO, Shaha AR, Netterville JL, Manni JJ and Ferlito A: Paragangliomas of the head and neck. Oral Oncol. 40:563–575. 2004. View Article : Google Scholar : PubMed/NCBI
17	Kasper GC, Welling RE, Wladis AR, CaJacob DE, Grisham AD, Tomsick TA, Gluckman JL and Muck PE: A multidisciplinary approach to carotid paragangliomas. Vasc Endovascular Surg. 40:467–474. 2006. View Article : Google Scholar : PubMed/NCBI
18	Lack EE, Cubilla AL and Woodruff JM: Paragangliomas of the head and neck region. A pathologic study of tumors from 71 patients. Hum Pathol. 10:191–218. 1979. View Article : Google Scholar : PubMed/NCBI
19	Anand VK, Alemar GO and Sanders TS: Management of the internal carotid artery during carotid body tumor surgery. Laryngoscope. 105:231–235. 1995. View Article : Google Scholar : PubMed/NCBI
20	Gardner P, Dalsing M, Weisberger E, Sawchuk A and Miyamoto R: Carotid body tumors, inheritance, and a high incidence of associated cervical paragangliomas. Am J Surg. 172:196–199. 1996. View Article : Google Scholar : PubMed/NCBI
21	Mitchell RO, Richardson JD and Lambert GE: Characteristics, surgical management, and outcome in 17 carotid body tumors. Am Surg. 62:1034–1037. 1996.PubMed/NCBI
22	Qin RF, Shi LF, Liu YP, Lei DL, Hu KJ, Feng XH, Nie X and Mao TQ: Diagnosis and surgical treatment of carotid body tumors: 25 years' experience in China. Int J Oral Maxillofac Surg. 38:713–718. 2009. View Article : Google Scholar : PubMed/NCBI