Open Access

The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer

  • Authors:
    • Liqun Wang
    • Di Liang
    • Xiaoli Xu
    • Jing Jin
    • Shumei Li
    • Guo Tian
    • Zhaoyu Gao
    • Congmin Liu
    • Yutong He
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/ol.2017.7047
  • Pages:6449-6456
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As the leading cause of cancer‑associated mortality globally among males in 2012, lung cancer is a disease of particular concern. Previously, the neutrophil‑to‑lymphocyte ratio (NLR) and the platelet‑to‑lymphocyte ratio (PLR) were revealed to be prognostic factors for various types of cancer, including lung cancer. In the present study, a retrospective review was conducted with patients who were diagnosed with lung cancer between January 1, 2000 and December 31, 2005 in the Fourth Hospital of Hebei Medical University. A total of 695 patients were included, and the optimal cutoffs of the NLR and the PLR were 6.0 and 248.0, respectively. There were statistically significant associations between tumor-node-metastasis (TNM) stage, surgery, metastasis incidence and NLR (P<0.001). The associations between TNM stage, surgery incidence and PLR were also revealed to be statistically significant (P<0.001). Patients in the low NLR group demonstrated longer overall survival (OS) than patients in the high NLR group (819.57 days vs. 629.86 days, P=0.041). The NLR at diagnosis was demonstrated to be an independent prognostic factor for OS. Thus, the NLR may be a promising approach for predicting the prognosis of patients with lung cancer.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Wang, L., Liang, D., Xu, X., Jin, J., Li, S., Tian, G. ... He, Y. (2017). The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer. Oncology Letters, 14, 6449-6456. https://doi.org/10.3892/ol.2017.7047
MLA
Wang, L., Liang, D., Xu, X., Jin, J., Li, S., Tian, G., Gao, Z., Liu, C., He, Y."The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer". Oncology Letters 14.6 (2017): 6449-6456.
Chicago
Wang, L., Liang, D., Xu, X., Jin, J., Li, S., Tian, G., Gao, Z., Liu, C., He, Y."The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer". Oncology Letters 14, no. 6 (2017): 6449-6456. https://doi.org/10.3892/ol.2017.7047