miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells

  • Authors:
    • Yongmei Chang
    • Wensen Yan
    • Cong Sun
    • Qingfeng Liu
    • Jun Wang
    • Mingzhi Wang
  • View Affiliations

  • Published online on: September 28, 2017     https://doi.org/10.3892/ol.2017.7092
  • Pages:6923-6928
0

Abstract

Lung cancer is one of the most common types of tumors and the leading cause of cancer‑associated mortality in the world. Additionally, non‑small cell lung cancer (NSCLC) accounts for ~80% of all lung cancer cases. Epithelial‑ mesenchymal transition (EMT) is an important cell biological process, which is associated with cancer migration, metastasis, asthma and fibrosis in the lung. In the present study, it was revealed that miR‑145‑5p was able to suppress EMT by inactivating the c‑Jun N‑terminal kinase (JNK) signaling pathway in NSCLC cells. Mitogen‑activated protein kinase kinase kinase 1 (MAP3K1) was predicted and confirmed to be a novel target of miR‑145‑5p. Overexpression of MAP3K1 was able to reverse the inhibition of EMT induced by miR‑145‑5p via the JNK signaling pathway. Overall, the results revealed that miR‑145‑5p inhibits EMT via the JNK signaling pathway by targeting MAP3K1 in NSCLC cells.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Chang, Y., Yan, W., Sun, C., Liu, Q., Wang, J., & Wang, M. (2017). miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells. Oncology Letters, 14, 6923-6928. https://doi.org/10.3892/ol.2017.7092
MLA
Chang, Y., Yan, W., Sun, C., Liu, Q., Wang, J., Wang, M."miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells". Oncology Letters 14.6 (2017): 6923-6928.
Chicago
Chang, Y., Yan, W., Sun, C., Liu, Q., Wang, J., Wang, M."miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells". Oncology Letters 14, no. 6 (2017): 6923-6928. https://doi.org/10.3892/ol.2017.7092