ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line

  • Authors:
    • Yang Jiang
    • Hui Li
    • Yi Wang
    • Tian Tian
    • Yan He
    • Yinji Jin
    • Changsong Han
    • Xiaoming Jin
    • Fengmin Zhang
    • Eiichi Morii
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/ol.2017.7057
  • Pages:6955-6961
0

Abstract

The present study aimed to examine whether the enzyme activity of aldehyde dehydrogenase (ALDH) was regulated by Nodal and histamine in the human alveolar adenocarcinoma A549 cell line. The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma. The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). ALDH activity was also downregulated by recombinant human Nodal and antagonists of H1R and H2R in the A549 cell line. In addition, expression of Nodal and ALDH1 were inversely correlated in lung mixed adenocarcinoma. ALDH enzyme activity was regulated by Nodal and histamine in lung adenocarcinoma.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y. ... Morii, E. (2017). ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncology Letters, 14, 6955-6961. https://doi.org/10.3892/ol.2017.7057
MLA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14.6 (2017): 6955-6961.
Chicago
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14, no. 6 (2017): 6955-6961. https://doi.org/10.3892/ol.2017.7057