Open Access

Implication of atypical supraclavicular F18‑fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer

  • Authors:
    • Takaaki Fujii
    • Reina Yajima
    • Hironori Tatsuki
    • Katsuya Oosone
    • Hiroyuki Kuwano
  • View Affiliations

  • Published online on: August 18, 2017     https://doi.org/10.3892/ol.2017.6768
  • Pages:7025-7030
  • Copyright: © Fujii et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been reported that F18‑fluorodeoxyglucose (FDG) uptake in the neck and supraclavicular lesions represents activated brown adipose tissue (BAT). In the present study, the association between BAT activity, detected by FDG‑positron emission tomography (PET), and the clinicopathological features of patients with breast cancer was investigated. The cases of 156 consecutive patients with breast cancer who underwent FDG‑PET preoperatively were analyzed. The distribution and intensity of atypical FDG uptake in the neck and/or supraclavicular region was reviewed. The intensity was graded as follows: 1, weak; 2, moderate; and 3, intense. Among the 156 patients, 70 (44.9%) exhibited grade 1 intensity, 65 (41.7%) exhibited grade 2 intensity and 21 (13.5%) exhibited grade 3 intensity. The intensity of FDG was significantly associated with human epidermal growth factor receptor 2 (HER2) expression and progesterone expression. Among the 156 patients, 6 (3.8%) had recurrent disease. Multivariate analysis revealed that showing a low grade of atypical FDG uptake was the only independent risk factor of short‑term recurrence, and none of the patients with recurrent disease had atypical FDG uptake that may reflect the activation of BAT. These results indicated that the presence of BAT is associated with HER2 expression and the absence of BAT may be a prognostic factor for breast cancer.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Fujii, T., Yajima, R., Tatsuki, H., Oosone, K., & Kuwano, H. (2017). Implication of atypical supraclavicular F18‑fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer. Oncology Letters, 14, 7025-7030. https://doi.org/10.3892/ol.2017.6768
MLA
Fujii, T., Yajima, R., Tatsuki, H., Oosone, K., Kuwano, H."Implication of atypical supraclavicular F18‑fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer". Oncology Letters 14.6 (2017): 7025-7030.
Chicago
Fujii, T., Yajima, R., Tatsuki, H., Oosone, K., Kuwano, H."Implication of atypical supraclavicular F18‑fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer". Oncology Letters 14, no. 6 (2017): 7025-7030. https://doi.org/10.3892/ol.2017.6768