Open Access

MiR‑124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6

  • Authors:
    • Li Yuan
    • Shaolin Li
    • Qi Zhou
    • Dong Wang
    • Dongling Zou
    • Jin Shu
    • Yu Huang
  • View Affiliations

  • Published online on: October 10, 2017     https://doi.org/10.3892/ol.2017.7157
  • Pages:7311-7317
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epithelial ovarian cancer remains the most common type of malignant tumor of the female reproductive system worldwide. Routine surgery and chemotherapy are the best treatments available for patients with ovarian cancer; however, almost 40% of ovarian cancer cases are intractable, with poor 5‑year survival rates. MicroRNAs (miRNA) are endogenous small non‑coding RNA molecules that function in transcriptional and post‑transcriptional regulation of gene expression in various cellular processes. Recent studies demonstrated that microRNA (miR)‑124 was downregulated in numerous types of tumors; however, the function and mechanism underlying miR‑124 in epithelial ovarian cancer remain unclear. The present study revealed that miR‑124 may be significantly downregulated in epithelial ovarian cancer. Using prediction algorithms and luciferase reporter gene assays, the present study identified and confirmed programmed cell death 6 (PDCD6) as a novel, direct target of miR‑124. Overexpression of miR‑124 suppressed PDCD6 expression, inhibited cell proliferation, migration and invasion, and induced apoptosis in SKOV3 and OCVAR3 cells in vitro. In the present study, overexpression of PDCD6 in epithelial ovarian cancer cells co‑transfected with miR‑124 effectively reversed the miR‑124‑induced apoptosis. Therefore, the results of the present study suggested that miR‑124 is a tumor suppressor miRNA and a potential target for future treatment of ovarian malignant neoplasms.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Yuan, L., Li, S., Zhou, Q., Wang, D., Zou, D., Shu, J., & Huang, Y. (2017). MiR‑124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6. Oncology Letters, 14, 7311-7317. https://doi.org/10.3892/ol.2017.7157
MLA
Yuan, L., Li, S., Zhou, Q., Wang, D., Zou, D., Shu, J., Huang, Y."MiR‑124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6". Oncology Letters 14.6 (2017): 7311-7317.
Chicago
Yuan, L., Li, S., Zhou, Q., Wang, D., Zou, D., Shu, J., Huang, Y."MiR‑124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6". Oncology Letters 14, no. 6 (2017): 7311-7317. https://doi.org/10.3892/ol.2017.7157