miR‑493 inhibits proliferation and invasion in pancreatic cancer cells and inversely regulated hERG1 expression
- Duo Zhi
- Xin Zhao
- Mei Dong
- Caichuan Yan
Published online on: October 12, 2017
Copyright: © Zhi et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
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The human ether‑a‑go‑go‑related potassium channel 1 (hERG1) is a component of the voltage‑gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. Pancreatic carcinoma is one of the most malignant human cancer types, which has an extremely poor prognosis. The present study demonstrated that the expression levels of hERG1 were markedly elevated in pancreatic cancer tissues and pancreatic cancer cell lines, and that the abnormal hERG1 expression was significantly associated with the proliferation and invasion ability of pancreatic cancer. Furthermore, hERG1 was identified to be a direct target of miR‑493, which is generally reduced in pancreatic cancer tissues and cell lines. These findings provide a novel insight into the regulatory mechanism of miR‑493/hERG1 in pancreatic cancer cell proliferation and invasion, which may aid the development of novel diagnostic and therapeutic strategies for pancreatic cancer in the future.