C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer

  • Authors:
    • Minjie Mao
    • Xiaoli Wei
    • Hui Sheng
    • Peidong Chi
    • Yijun Liu
    • Xiaoyan Huang
    • Yifan Xiang
    • Qianying Zhu
    • Shan Xing
    • Wanli Liu
  • View Affiliations

  • Published online on: October 13, 2017     https://doi.org/10.3892/ol.2017.7179
  • Pages:7417-7424
0

Abstract

Multiple studies have reported the prognostic association of certain inflammatory factors with various types of cancer. The present study assessed the prognostic value of the C‑reactive protein (CRP)/albumin (Alb) ratio and the neutrophil/lymphocyte ratio (NLR), separately and in combination, in gastric cancer (GC). A total of 337 cases pathologically diagnosed with gastric adenocarcinoma were retrospectively evaluated. The clinicopathological and prognostic relevance of the CRP/Alb ratio and NLR and their combination were analyzed. The optimal cut‑off values of the CRP/Alb ratio and NLR were 0.38 and 3.14, respectively. High CRP/Alb ratio (≥0.38) and NLR (≥3.14) values were associated with increased tumor invasion, more distant metastasis and a more advanced tumor‑node‑metastasis stage (all P<0.05). In addition, a high NLR value was also associated with increased tumor size (P=0.02). The CRP/Alb ratio (≥0.38/<0.38) and NLR (≥3.14/<3.14) were independent prognostic factors for overall survival time (OS) in GC by multivariate analysis (P=0.005 and P=0.001). Using the CRP/Alb ratio and NLR classification, patients were stratified into three subgroups with different OS time (P<0.001), which were identified as independent prognostic variables in multivariate analysis (P<0.001). The present study demonstrated that the CRP/Alb ratio and NLR were independent prognostic factors for OS in patients with GC. The combination of these indexes was associated with significant prognostic value and may further stratify prognosis.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X. ... Liu, W. (2017). C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncology Letters, 14, 7417-7424. https://doi.org/10.3892/ol.2017.7179
MLA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14.6 (2017): 7417-7424.
Chicago
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14, no. 6 (2017): 7417-7424. https://doi.org/10.3892/ol.2017.7179