Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells
- Lijun Qu
- Sumei Li
- Yumin Zhuo
- Jianfan Chen
- Xiaoping Qin
- Guoqing Guo
Published online on: October 9, 2017
Copyright: © Qu et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. G. lucidum has been associated with prostate cancer cells. G. lucidum extracts contain numerous bioactive components; however, the exact functional monomer is unknown and the role of triterpenes from G. lucidum (GLT) in prostate cancer remain obscure. The present study investigated the effects of GLT on cell viability, migration, invasion and apoptosis in DU‑145 human prostate cancer cells. The results demonstrated that a high dose (2 mg/ml) of GLT inhibits cell viability in a dose‑ and time‑dependent manner by the regulation of matrix metalloproteases. Furthermore, GLT induced apoptosis of DU‑145 cells. In general, GLT exerts its effect on cancer cells via numerous mechanisms and may have potential therapeutic use for the prevention and treatment of cancer.