Liver X receptors as potential targets for cancer therapeutics (Review)

  • Authors:
    • Xiaoli Ju
    • Pan Huang
    • Miao Chen
    • Qiang Wang
  • View Affiliations

  • Published online on: October 23, 2017     https://doi.org/10.3892/ol.2017.7259
  • Pages:7676-7680
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Abstract

Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Previous studies have suggested that LXRs are also involved in numerous types of cancer and are therefore potential targets for cancer therapeutics. The present review summarizes LXR ligands and their mechanisms of action, the effects of LXRs in different types of cancer and their potential applications in clinical treatment. Together, the studies discussed in the present review indicate that LXRs may be potential targets for cancer therapeutics.

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Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Ju, X., Huang, P., Chen, M., & Wang, Q. (2017). Liver X receptors as potential targets for cancer therapeutics (Review). Oncology Letters, 14, 7676-7680. https://doi.org/10.3892/ol.2017.7259
MLA
Ju, X., Huang, P., Chen, M., Wang, Q."Liver X receptors as potential targets for cancer therapeutics (Review)". Oncology Letters 14.6 (2017): 7676-7680.
Chicago
Ju, X., Huang, P., Chen, M., Wang, Q."Liver X receptors as potential targets for cancer therapeutics (Review)". Oncology Letters 14, no. 6 (2017): 7676-7680. https://doi.org/10.3892/ol.2017.7259