Open Access

Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer

  • Authors:
    • Gaixia Lu
    • Da Fu
    • Chengyou Jia
    • Li Chai
    • Yang Han
    • Jin Liu
    • Tingmiao Wu
    • Ruting Xie
    • Zhengyan Chang
    • Huiqiong Yang
    • Pei Luo
    • Zhongwei Lv
    • Fei Yu
    • Xiaojun Zhong
    • Yushui Ma
  • View Affiliations

  • Published online on: October 19, 2017     https://doi.org/10.3892/ol.2017.7228
  • Pages:7842-7848
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

0

Abstract

Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR‑105‑1 expression in 32 normal lung and 142 non‑small cell lung cancer (NSCLC) tissue samples using reverse transcription‑quantitative polymerase chain reaction. Survival data were calculated using Kaplan‑Meier curves and a log‑rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR‑105‑1 expression in different types of human cancer, particularly in NSCLC. The level of miR‑105‑1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR‑105‑1 expression was associated with larger tumor size as well as poor OS and disease‑free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR‑105‑1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR‑105‑1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients.

Related Articles

Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J. ... Ma, Y. (2017). Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer. Oncology Letters, 14, 7842-7848. https://doi.org/10.3892/ol.2017.7228
MLA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14.6 (2017): 7842-7848.
Chicago
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14, no. 6 (2017): 7842-7848. https://doi.org/10.3892/ol.2017.7228