Open Access

Identification and validation of PSAT1 as a potential prognostic factor for predicting clinical outcomes in patients with colorectal carcinoma

  • Authors:
    • Cheng Qian
    • Yongsheng Xia
    • Yun Ren
    • Yan Yin
    • Anmei Deng
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/ol.2017.7211
  • Pages:8014-8020
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the existence of known or candidate drug‑target genes that are upregulated in colorectal cancer (CRC) and may serve as novel prognostic factors or therapeutic targets for this type of malignancy. An in silico analysis was conducted using the Oncomine tool to compare the expression levels of a list of drug‑target genes between cancerous and normal tissues in 6 independent CRC cohorts retrieved from the Oncomine database. Phosphoserine aminotransferase 1 (PSAT1) was identified as the top‑ranked upregulated gene in CRC tumors, and was highly expressed in patients with chemoresistant disease. Subsequently, the expression of PSAT1 was further experimentally validated using immunohistochemistry in an independent cohort of CRC specimens. The immunohistochemistry results demonstrated that PSAT1 was overexpressed in the CRC tissues compared with the normal colorectal tissues, which was consistent with the previous in silico analysis. Furthermore, PSAT1 overexpression was associated with response to irinotecan, 5‑fluorouracil and leucovorin chemotherapy, and with shorter survival time, and retained significance as an independent prognostic factor for CRC when subjected to the multivariate analysis with a Cox's proportional hazards model. Therefore, the present results implicate PSAT1 as a potential prognostic biomarker and a promising therapeutic target for CRC. Targeted PSAT1 inhibition in the treatment of CRC warrants further investigation.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Qian, C., Xia, Y., Ren, Y., Yin, Y., & Deng, A. (2017). Identification and validation of PSAT1 as a potential prognostic factor for predicting clinical outcomes in patients with colorectal carcinoma. Oncology Letters, 14, 8014-8020. https://doi.org/10.3892/ol.2017.7211
MLA
Qian, C., Xia, Y., Ren, Y., Yin, Y., Deng, A."Identification and validation of PSAT1 as a potential prognostic factor for predicting clinical outcomes in patients with colorectal carcinoma". Oncology Letters 14.6 (2017): 8014-8020.
Chicago
Qian, C., Xia, Y., Ren, Y., Yin, Y., Deng, A."Identification and validation of PSAT1 as a potential prognostic factor for predicting clinical outcomes in patients with colorectal carcinoma". Oncology Letters 14, no. 6 (2017): 8014-8020. https://doi.org/10.3892/ol.2017.7211