Open Access

Increased expression of the high‑mannose M6N2 and NeuAc3H3N3M3N2F tri‑antennary N‑glycans in cholangiocarcinoma

  • Authors:
    • Krajang Talabnin
    • Chutima Talabnin
    • Mayumi Ishihara
    • Parastoo Azadi
  • View Affiliations

  • Published online on: November 9, 2017     https://doi.org/10.3892/ol.2017.7384
  • Pages:1030-1036
  • Copyright: © Talabnin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Changes in protein glycosylation have been reported in various types of cancer, including cholangiocarcinoma (CCA). Nanospray ionization‑linear ion trap mass spectrometry (NSI‑MSn) was used in the present study to determine the comparative structural glycomics of the N‑linked glycans in the serum of patients with CCA compared with healthy controls. A total of 5 high‑mannose and 4 complex N‑linked glycans were detected. Mannose7‑N‑acetyl‑glucosamine2 was the most abundant structure among the high‑mannose types (control 12.12±2.54 vs. CCA 9.27±2.66%), whereas NeuAc2H2N2M3N2 predominated the complex types (control 61.17±2.55 vs. CCA 64.68±4.23%). The expression of 3 different N‑glycans differed significantly between the CCA cases and controls. These included mannose6‑N‑acetyl‑glucosamine2 (P=0.044), mannose9‑N‑acetyl‑glucosamine2 (Ρ=0.030) and NeuAc3H3N3M3N2F (Ρ=0.002). These three glycan structures may therefore be associated with tumor progression in CCA and may be useful for its diagnosis.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
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APA
Talabnin, K., Talabnin, C., Ishihara, M., & Azadi, P. (2018). Increased expression of the high‑mannose M6N2 and NeuAc3H3N3M3N2F tri‑antennary N‑glycans in cholangiocarcinoma. Oncology Letters, 15, 1030-1036. https://doi.org/10.3892/ol.2017.7384
MLA
Talabnin, K., Talabnin, C., Ishihara, M., Azadi, P."Increased expression of the high‑mannose M6N2 and NeuAc3H3N3M3N2F tri‑antennary N‑glycans in cholangiocarcinoma". Oncology Letters 15.1 (2018): 1030-1036.
Chicago
Talabnin, K., Talabnin, C., Ishihara, M., Azadi, P."Increased expression of the high‑mannose M6N2 and NeuAc3H3N3M3N2F tri‑antennary N‑glycans in cholangiocarcinoma". Oncology Letters 15, no. 1 (2018): 1030-1036. https://doi.org/10.3892/ol.2017.7384