search button
Open Access

miR‑373‑3p promotes lung adenocarcinoma cell proliferation via APP

  • Authors:
    • Xiaoxi Fan
    • Shun Xu
    • Chunlu Yang

  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/ol.2017.7372
  • Pages: 1046-1050

  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies have indicated that lung adenocarcinoma (LUAD) is one of the common human malignancies, and its incidence keeps rising. With the help of microarray technology, downregulation of miR‑373‑3p was observed in LUAD tissues compared with normal lung tissues. Notably, the present study demonstrated that the expression of amyloid precursor protein (APP) mRNA in LUAD tissues was overexpressed compared with adjacent tissues. Bioinformatic analysis demonstrated that miR‑373‑3p may interact with the 3' untranslated region of APP mRNA, and then western blot and dual‑luciferase reporter gene assays were employed to verify the interaction. Finally, CCK‑8 assays were used to measure the tumor‑suppressing effect of miR‑373‑3p on A549 and it was demonstrated that overexpression of miR‑373‑3p may more effectively inhibit the proliferation of A549 compared with APP si‑RNA. Overall, the findings suggest that miR‑373‑3p downregulation partly accounts for APP overexpression and leads to a promotion of cell growth in LUAD. miR‑373‑3p may therefore act as a valuable target in potential anticancer strategies to treat LUAD.
View Figures
View References

Related Articles

Journal Cover

January-2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Fan X, Xu S and Yang C: miR‑373‑3p promotes lung adenocarcinoma cell proliferation via APP. Oncol Lett 15: 1046-1050, 2018
APA
Fan, X., Xu, S., & Yang, C. (2018). miR‑373‑3p promotes lung adenocarcinoma cell proliferation via APP. Oncology Letters, 15, 1046-1050. https://doi.org/10.3892/ol.2017.7372
MLA
Fan, X., Xu, S., Yang, C."miR‑373‑3p promotes lung adenocarcinoma cell proliferation via APP". Oncology Letters 15.1 (2018): 1046-1050.
Chicago
Fan, X., Xu, S., Yang, C."miR‑373‑3p promotes lung adenocarcinoma cell proliferation via APP". Oncology Letters 15, no. 1 (2018): 1046-1050. https://doi.org/10.3892/ol.2017.7372