MicroRNA‑138 targets SP1 to inhibit the proliferation, migration and invasion of hepatocellular carcinoma cells
- Chongzhong Liu
- Jiankang Zhu
- Fengyue Liu
- Yadong Wang
- Min Zhu
Published online on: November 8, 2017
The identification of microRNAs (miRNAs/miRs) has enabled the improved understanding of the carcinogenesis and progression of hepatocellular carcinoma (HCC). miRNAs are small non‑coding RNAs comprised of 19‑24 nucleotides that regulate the expression of target genes. In the present study, miR‑138 was demonstrated to be downregulated in human HCC tissues and cell lines. Restoration of miR‑138 expression repressed the proliferation, migration and invasion of HCC cells. Furthermore, specificity protein 1 (SP1) was identified as a target gene of miR‑138 in HCC using bioinformatics analysis, luciferase reporter assay, reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Knockdown of SP1 produced similar suppressive effects to those induced by miR‑138 overexpression in HCC cells. These results indicate that miR‑138 targeted SP1 to repress the growth, migration and invasion of HCC cells, and may therefore represent a therapeutic target in human HCC.