Open Access

Carcinoma associated fibroblasts derived from oral squamous cell carcinoma promote lymphangiogenesis via c-Met/PI3K/AKT in vitro

  • Authors:
    • Pan Gao
    • Chunjie Li
    • Zheng Chang
    • Xiaoyi Wang
    • Ming Xuan
  • View Affiliations

  • Published online on: October 31, 2017     https://doi.org/10.3892/ol.2017.7301
  • Pages:331-337
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Carcinoma-associated fibroblasts (CAFs) are dominant components of the tumor microenvironment (TME) that promote the development, progression and metastasis of cancer. c‑Met is a receptor of the hepatocyte growth factor (HGF), which is involved in lymphangiogenesis. Currently, the roles of CAFs during lymphangiogenesis are unknown. It has been hypothesized that CAFs contribute to lymphangiogenesis of oral squamous cell carcinoma (OSCC) via a HGF/c‑Met complex. The expression of HGF in OSCC was determined using CAFs derived from OSCC tissue and it was demonstrated that HGF is overexpressed in OSCC‑derived CAFs. It was also revealed that c‑Met was highly expressed in human lymphatic endothelial cells (HLECs) when co‑cultured with CAFs. Furthermore, it was demonstrated that recombinant human HGF significantly enhanced the proliferation, migration, invasion and tube formation of HLECs. By contrast, the inhibition of c‑Met expression suppressed the aforementioned biological activities and also downregulated the expression of c‑Met, phosphoinositide 3‑kinase and phosphorylated protein kinase B. Taken together, these data demonstrate that c‑Met is associated with the regulation of lymphangiogenesis. Thus, the results of the present study indicate that c‑Met may be a promising novel therapeutic target to treat patients with OSCC.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Gao, P., Li, C., Chang, Z., Wang, X., & Xuan, M. (2018). Carcinoma associated fibroblasts derived from oral squamous cell carcinoma promote lymphangiogenesis via c-Met/PI3K/AKT in vitro. Oncology Letters, 15, 331-337. https://doi.org/10.3892/ol.2017.7301
MLA
Gao, P., Li, C., Chang, Z., Wang, X., Xuan, M."Carcinoma associated fibroblasts derived from oral squamous cell carcinoma promote lymphangiogenesis via c-Met/PI3K/AKT in vitro". Oncology Letters 15.1 (2018): 331-337.
Chicago
Gao, P., Li, C., Chang, Z., Wang, X., Xuan, M."Carcinoma associated fibroblasts derived from oral squamous cell carcinoma promote lymphangiogenesis via c-Met/PI3K/AKT in vitro". Oncology Letters 15, no. 1 (2018): 331-337. https://doi.org/10.3892/ol.2017.7301