Open Access

Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study

  • Authors:
    • Mónica Molano
    • Diana Carolina Martín
    • Pablo Moreno‑Acosta
    • Gustavo Hernández
    • Alyssa Cornall
    • Oscar Buitrago
    • Oscar Gamboa
    • Suzanne Garland
    • Sepehr Tabrizi
    • Nubia Muñoz
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/ol.2017.7324
  • Pages:354-360
  • Copyright: © Molano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epidemiological information on telomerase activity (TA) and development of cervical lesions is scarce. A nested case-control study was carried out within a cohort of Colombian women tested for Human Papillomavirus (HPV). Measurement of TA was done in cervical scrapes of 25 women who developed High Grade Squamous Intraepithelial Lesion (HGSIL) during the first 6 years of follow‑up and was compared with that of 104 control women who maintained normal cytology during the entire follow‑up. TA was measured by Tartrate resistant acid phosphatase‑ELISA. TA and HPV infections were significantly more frequent in cases than in controls. Likewise, 68% of the cases were positive for both TA and HPV compared with only 7.7% of the controls (P<0.0001). Factors independently associated with increased odds of HGSIL included TA, high risk HPV (hrHPV) infections and multiple parities. When restricted to hrHPV positive women, TA was strongly associated with increased odds of HGSIL (adjusted odds ratio=37.94, 95% confidence interval, 1.64‑678.1). In addition to an infection with hrHPV, TA appears to be a significant cofactor for HGSIL.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Molano, M., Martín, D.C., Moreno‑Acosta, P., Hernández, G., Cornall, A., Buitrago, O. ... Muñoz, N. (2018). Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study. Oncology Letters, 15, 354-360. https://doi.org/10.3892/ol.2017.7324
MLA
Molano, M., Martín, D. C., Moreno‑Acosta, P., Hernández, G., Cornall, A., Buitrago, O., Gamboa, O., Garland, S., Tabrizi, S., Muñoz, N."Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study". Oncology Letters 15.1 (2018): 354-360.
Chicago
Molano, M., Martín, D. C., Moreno‑Acosta, P., Hernández, G., Cornall, A., Buitrago, O., Gamboa, O., Garland, S., Tabrizi, S., Muñoz, N."Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study". Oncology Letters 15, no. 1 (2018): 354-360. https://doi.org/10.3892/ol.2017.7324