Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas

  • Authors:
    • Ting‑Ting Liu
    • Hao Wang
    • Feng Juan Wang
    • Yu Feng Xi
    • Li Hua Chen
  • View Affiliations

  • Published online on: November 2, 2017     https://doi.org/10.3892/ol.2017.7333
  • Pages:533-537
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Abstract

Neurotrophic factors (NTFs) are well known to serve critical functions in neural survival, neurite growth and cell differentiation in vivo and in vitro. Previous progress has indicated that nerve growth factor (NGF) and brain‑derived neurotrophic factor (BDNF), two NTF family members, may be involved in the process of tumor progression. In the present study, the expression of NGF and BDNF was detected using immunohistochemistry on 70 adult astrocytoma samples collected from distinct locations as well as of various pathological grades, with an additional 15 samples being collected from normal adult brain tissue to be used as controls. NGF and BDNF were identified to be expressed in all samples, and their positive cell expression rates in astrocytomas demonstrated a significant increase compared with that in the normal controls (P<0.05), particularly in grade III (P<0.05). In addition, the expression of NGF and BDNF exhibited a gradual decrease ranging from the temporal lobe, parietal lobe and cerebellum to the frontal lobe (P<0.05). The results of the present study suggest that the expression of NGF and BDNF is increased in astrocytomas, which is associated with the pathological grade and the astrocytoma location.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
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APA
Liu, T., Wang, H., Wang, F.J., Xi, Y.F., & Chen, L.H. (2018). Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas. Oncology Letters, 15, 533-537. https://doi.org/10.3892/ol.2017.7333
MLA
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15.1 (2018): 533-537.
Chicago
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15, no. 1 (2018): 533-537. https://doi.org/10.3892/ol.2017.7333